alexa The Recovery Of Oxyhaemoglobin In Haemolysate By Desferal (DFO) And Defriprone (L1) That Are Currently In Clinic Use For The Treatment Of Transfusional Iron Overlaod In Beta Thalassemia Major Patients
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th Annual European Pharma Congress
June 26-28, 2017 Madrid, Spain

Hicham H Khodr, Mustafa Ibrahim, Israa Mahmoud Moursi, Anjud Khamis Al-Mohannadi and Gary Tilbrook
Texas A&M University at Qatar, Qatar
Qatar University, Qatar
GST Pharma Limited, Cambridge, UK
Posters & Accepted Abstracts: Pharmaceut Reg Affairs
DOI: 10.4172/2167-7689-C1-025
Abstract
The development of potent metal chelators has a great benefit in medicine, agriculture and industry. Surprisingly, the clinically use of defriprone (L1) in synergism with desferal (DFO) as potent metal chelators for the treatment of iron (III) overload in thalassemic patients, has additional clinical applications such as inhibiting prostate cancer proliferation at clinically relevant doses and plasma concentrations. Furthermore, the bidentate ligand L1 and hexadentate ligand DFO exhibit a great effect by recovering the oxyhaemoglobin from the iron-mediated oxidative damage on oxy-haemoglobin in haemolysed red blood cells after five minutes of iron addition (data not published yet). In this work, physical and chemical properties (pKas and β) values of L1 and DFO were used to theoretically show the potential of DFO over L1 in complexing iron (III). These simulations might offer an insight into which compound recovers faster the oxidative damage from oxyhaemoglobin that occurs in blood haemolysate associated with an accumulation of iron (III). This study shows that 0.5 mM DFO recover 95% of the oxidative damage of oxyhaemoglobin faster than that of 0.5 mM L1. This was measured by monitoring the absorbance in the visible region between 500 nm and 800 nm of the oxyheamoglobin with varying concentrations of iron (III) from 50 μM to 250 μM in 50 increment steps at physiological pH using 50 mM phosphate buffer in the presence and absence of L1 and DFO. The potential medical application of these compounds would be useful to prevent oxidative damage that occurs as a result of red blood cell haemolysis with the commensurate release of oxyhaemoglobin, that contributes to acute and chronic vascular disease, inflammation, thrombosis, and renal impairment.
Biography

Hicham H Khodr obtained his PhD in NMR studies of ligand-Ferritin interaction. He is an expert in NMR spectroscopy and programming. He had developed an autotitration system at King’s College London Pharmacy, UK. This system enables us to study the physicchemical properties of many compounds that of agriculture and clinical uses. Furthermore, he worked with Prof. Hider group at KCL, Pharmacy in the area of synthesis and characterization of new candidate compounds as pro drug for the treatment of b-thalassemia major. His major target is to develop new candidate compounds (bidentate and tetradentate) for preventing the oxidative damage in red blood cell haemolysis as well as for the treatment of β-thalassemia major.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords