alexa The Relationship Between Leptin Serum Concentrations And Hypertension In Patients On The End Stage Of Renal Disease
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

11th International Conference on Nephrology & Urology
March 22-23, 2017 Rome, Italy

Vaia D Raikou and Despina Kyriaki
Doctors Hospital, Greece
General Hospital Laiko, Greece
Posters & Accepted Abstracts: J Nephrol Ther
DOI: 10.4172/2161-0959.C1.037
Introduction & Aim: Leptin modifies the systemic inflammatory response and insulin action, but the mechanisms by which it affects vascular disease is unclear. We studied the relationship between leptin serum concentrations and hypertension in intermittent hemodialysis patients. Methods: We studied 47 patients on on-line hemodiafiltration. Dialysis adequacy was defined by Kt/V for urea leptin and insulin was measured by radioimmunoassay. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Serum bicarbonate levels were measured in gas machine. We recorded the blood pressure as the mean of 10 measurements during a treatment month. Kaplan-Meier curve and Cox regression model were performed to predict the role of leptin levels on established hypertension. Results: Leptin serum concentrations were positively associated with insulin and BMI (r=0.331, p=0.02 and r=0.453, p=0.001 respectively). Kaplan-Meier analyses showed that leptin serum concentrations less than the mean value equal to 8.12 ng/ml were significantly associated with both, established hypertension and defined by serum bicarbonate less than 22 mmol/L metabolic acidosis state (log-rank=9.7, p=0.002 and log-rank=3.6, p=0.04 respectively). Cox-regression analysis showed that leptin was an inverse significant factor for existed hypertension after adjustment for covariates. Conclusion: We observed inverse association between high leptin serum concentrations and hypertension in intermittent hemodialysis patients. The underlying pathophysiological mechanisms for such relationship may comprise the acquired higher leptin resistance, coexistence of normal body adiposity and corrected metabolic acidosis state.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version