The Renal Function Parameters Of HIV-1 Infected Patients Receiving Highly Active Antiretroviral Therapy At Federal Teaching Hospital Abakaliki, Ebonyi State | 19654
Journal of Clinical & Cellular Immunology
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The impact of HIV infection has become a global threat. This is more felt in rural areas with poor economic and social
background. Highly active antiretroviral therapy (HAART) is anticipated to result in an increase in long-term survival,
but may present with the development of associated complications. The effect of HAART on renal function is currently being
explored. This study is aimed to ascertain the renal function parameters of HIV-1 infected patients receiving HAART in rural
settings of Ebonyi State, Nigeria. Five hundred and eighty eight patients within the age range of 23-67 years comprising of
260 females and 328 males were enrolled for this study. This study was carried out at the Federal Teaching Hospital Abakaliki
where the subjects were registered and placed on antiretroviral therapy and assessed for eighteen months with respect to renal
function parameters such as creatinine and urea in correlation with CD4+ T-cell count. Demographic parameters (age, sex
and social status) of the study subjects was collected using structured pretested questionnaire at their follow up date. The result
revealed that 168 (28%) patients showed elevated serum urea and creatinine values above normal range as indicated by mean
values of 73.4 mg/dl and 4.12 mg/dl from initial values of 51.32 mg/dl and 1.34 mg/dl at baseline respectively in the 18th month
respectively the value are significant as p<0.05 and had a correlations coefficient of 0.975, 0.829 at 0.01 level with CD4+ T-cell.
Subsequently, the CD4+ T-cell count increased from mean value of 89?13 cell/μl to 581?45 cell/μl at 18th months. The result
shows that while the antiretroviral therapy may show good prognosis when considered on the basis of CD4+ T-cell turn over
the impact on renal function is significantly deleterious. The treatment of HIV infected person with antiretroviral is receiving
wider attention, the side effects of these drugs are continually manifesting among some recipients especially in rural poor
settings. This may not be unconnected with concomitant administration of other drugs such as antimalarial. Hence therefore
the need for close and proper monitoring of patients on antiretroviral therapy for adverse effect on renal function parameters
and also to aid in evaluating drug combinations and implement dose modifications when necessary.
Moses Nnaemek Alo studied Microbiology (BSc) from University of Lagos, Nigeria. He went further to study Medical Immunology in Masters Degree (MSc) from
Ebonyi State University, Nigeria and also obtained a PhD in Medical Microbiology from Ebonyi State University, Nigeria. He also has a professional qualification
in Medical Microbiology registriable with Medical Registration Council of Nigeria. His research areas include infectious diseases, public health, immunology and
medical bacteriology and virology. He has been the Head of Department of Medical Laboratory Science from 2007-2011 at Ebonyi State University, Nigeria, member
Medical Laboratory Science of Nigeria, and currently is the program coordinator Microbiology in Federal University Ndufu-Alike Ikwo, Nigeria. He is involved in
various researches both at Undergraduate and Postgraduate level. He is currently a Research Coordinator in Microbiology and Epidemiology of Water Borne
Infectious Disease in Federal University Ndufu-Alike Ikwo, Nigeria. He has over 50 publications to his credit.
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