alexa The Role Of Cellular Lipid Droplets In Rotavirus Replication: Compounds Disturbing Lipid Droplet Homeostasis Decrease Rotavirus Replication
ISSN: 2161-0517

Virology & Mycology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

9th International Virology Congress and Expo
March 13-14, 2017 London, UK

Ulrich Desselberger
University of Cambridge, UK
ScientificTracks Abstracts: Virol Mycol
DOI: 10.4172/2161-0517.C1.017
Abstract
Rotaviruses (RVs) are a major cause of severe gastroenteritis in infants and young children worldwide. Rotavirus-associated disease is associated with a mortality of >200,000 children/annum. Rotavirus vaccines licensed since 2006 have significantly decreased RV-associated disease and mortality, however with variable efficacy. The molecular biology of RV replication is well studied. Recently, the interaction of viroplasms (cytoplasmic inclusion bodies in which RV RNA replication and early morphogenesis take place) with the cellular organelles lipid droplets (LDs) has been discovered. Viroplasms recruit LDs early during viral replication. Compounds disturbing LD homeostasis (in non-toxic concentrations), such as inhibitors of fatty acid biosynthesis (TOFA, C75 and Triacsin C) or compounds eliciting lipolysis (isoproterenol+IBMX), inhibit RV replication by 4-6-fold (viral RNA replication) and 20-50-fold (infectivity of viral progeny). Compounds disturbing LD homeostasis may have the potential to become antivirals.
Biography

Ulrich Desselberger is the Professor in the Department of Medicine, University of Cambridge, UK. He is having above 100 publications in peer review journals.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords