alexa
Reach Us +1-217-403-9671
The Role Of Hydrophilic Porphyrin-[C60] Fulleropyrrolidine Dyads As Nano-assisted Photosensitizers Towards Cancer Photo Dynamic Therapy (PDT) | 7376
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

The role of hydrophilic porphyrin-[C60] fulleropyrrolidine dyads as nano-assisted photosensitizers towards cancer photo dynamic therapy (PDT)

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Devashish Sengupta

ScientificTracks Abstracts: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.002

Abstract
Nanoparticles are non-immunogenic and fail to elicit any immune response when introduced into the body?s circulatory system, which could otherwise lead to severe consequences like shutting off or blockage of the circulatory system. However, strong functionalization of nanoparticles like fullerenes with supramolecular photosensitizers (PS) can solve the problem and help develop nano-assisted PS with efficient applications in cancer photodynamic therapy (PDT). Hydrophilic porphyrinfulleropyrrolidine dyads of various topologies, consisting of meso- substituted pyridinium derivatives, covalently-linked to a fulleropyrrolidine, have shown selective cytotoxic action towards ovarian cancer cells. These compounds are expected to be produced in an optically transparent form. Thus, light activation and optical probing can readily be accomplished for efficient generation of Reactive Oxygen Species (ROS). This is expected to enhance their role as anti-cancer agents. Depending upon their subcellular and submicron size, the C60 or C70 particles present in these PS can penetrate deep into tissues through fine capillaries and are able to pass through the fenestrate into the endothelial cells lining the blood vessels. The gel electrophoresis results indicated efficient cleavage of pUC DNA under light irradiated conditions. In the in vitro MTT cancer cell assays, the dyads inhibited the growth of ovarian cancer cells more significantly than it did the other adenocarcinoma epithelial cell lines like stomach, liver, lung etc. The most interesting outcomes of the study revealed that their biological activities with respect to cytotoxicity and DNA cleavage was higher and specific for dyads that experienced lower π-π interactions and showed higher fluorescence quantum yields. These results indicate great promise for the possible replacement of the controversial yet commercially available PS like photofrin, vasudyne etc with such dyads.
Biography
Devashish Sengupta obtained his PhD from The University of Sydney, Australia in 2007. His work was based on biomolecular medicinal chemistry of photosensitizers. He joined Assam University, India as an Assistant Professor in 2008. His research interest focuses on medicinal organic chemistry of fullerenes and porphyrin analogues. He is dedicated to the study of Structure Activity Relationships (SAR) of different nano-assisted photosensitizers and their relevance to pharmacology. He is working on two major projects recommended by DBT and collaborating with NIMHANS, Bangalore and ICGEB, Delhi. His present research ventures explore the applications of structurally modified molecular topologies of fullerene derivatives towards Perkinson?s Disease (PD), retro-virus (HIV-1) and cancer PDT.
Top