alexa The Role Of Scaffold Proteins In Information Transfer In Cellular Signaling
ISSN: 0974-7230

Journal of Computer Science & Systems Biology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Summit on Integrative Biology
August 04-05, 2014 Hilton-Chicago/Northbrook, Chicago, USA

Veronica Parasco, Michelle Wynn, Jacques-Alexandre Sepulchre, Sofia Merajver, Alejandro Colman-Lerner and Alejandra C Ventura
Accepted Abstracts: J Comput Sci Syst Biol
DOI: 10.4172/0974-7230.S1.009
Mammalian cells contain about 1 trillion of protein molecules with approximately 10% of which are involved in signal transduction. Given the enormous number of molecules, it is surprising that cells can accurately process the large amount of information they receive constantly. Even so, different signals are often transmitted by common components yet elicit distinct (and appropriate) outcomes. How specificity from signal to cellular response is maintained between different signal transduction pathways that share similar (or identical) components? In the recent decades the notion that cells organize subgroups of proteins in space and time has appeared. In this direction and about 15 years ago, the first scaffold proteins were discovered. Different isolated components from the signaling network have been extensively studied and characterized in order to then predict the behavior of the integrated system from the behavior of its parts. This notion is based on the hypothesis that the properties of the individual components are not altered as these are interconnected, which is known as "modular organization". However, our work and that of others has shown theoretically and experimentally that bio-molecular systems cannot always be connected modularly: the dynamics of the interconnection can dramatically change the behavior of connected modules, an effect that has been called retroactivity. We have characterized the interaction between scaffold proteins and retroactivity through a combination of analytical and computational tools using cascades of covalent modification cycles.
Veronica Parasco has completed his PhD at the age of 28 years from Buenos Aires University, Argentina, and postdoctoral studies from Michigan University, USA. She is now a researcher at Buenos Aires University. She has published almost 30 papers in high impact factor journals in the area of systems biology, mathematical modeling and physical and computational biology.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version