ureka moments are rare in modern science and most advances are gained in small increments repeating
the work to ensure the findings are true. In a complex topic such as immunology the incremental
approach has intellectual rigour but is very slow. At some point it may be worthwhile taking an educated
guess at how it all links up. To take such a leap requires a different mindset and is not an approach likely
to be enthusiastically supported by those who have hewn hard-won facts from the incremental rock face.
Furthermore it is likely that a person who takes on such a project will be outside of mainstream thinking
and inevitably place different interpretations on the work of others. My specific topic concerns the role
of MHC in transplantation with the underlying hypothesis being that the MHC has a key role in tolerance
induction. The target audience will be scientists and clinicians who are not immunologists and the
presentation will be made as jargon-free as possible.e progress made in the validation of these biomarkers
and their availability for clinical use in the near future.
Derek Gray trained in Oxford UK in vascular and general surgery specializing in transplantation followed by 5 years
as transplant physician. His research interests include islet transplantation and transplant immunology. Author of more
than 100 papers in refereed journals
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