alexa The Use Of Biomarkers To Characterize Colorectal Cancer: From Genetic Make-up To Complex Phenotypic Measurement
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

5th International Conference on Biomarkers & Clinical Research
April 15-17, 2014 St. Hilda’s College - University of Oxford, UK

P. Vodicka, J. Slyskova, B. Pardini, A. Naccarati, L. Vodickova, L. Bielik, V. Polakova, P. Prochazka, M. Svoboda, M. Burocziova, P. Soucek, J. Hesketh, S. Landi, R. Kumar, F. Canzian, A. Foersti and K. Hemmiki
ScientificTracks Abstracts: J Mol Biomark Diagn
DOI: 10.4172/2155-9929.S1.021
Abstract
M ajority of cancer cases occurs sporadically as a consequence of complex interplay between genetic variants and environmental factors. Colorectal carcinogenesis (CRC) involves a plethora of events, such as uncontrolled proliferation and genomic instability, which point to the DNA repair and DNA damage response as to the key players. Here we overview several biomarkers in mapping heterogenous complex disease, which poses a serious health problem worldwide, and provide an excursion into the DNA repair phenotypic reflection in control individuals and CRC patients. Gene variants involved in pathways, such as DNA repair, cell cycle control, folate metabolism and methylation, insulin resistance and obesity, ABC transporters, seleno proteins, inflammatory/immune response have shown various degree of association with CRC risk. Gene expression levels in relevant pathways were complemented with transcription regulations by methylation. Post-transcriptional regulation via miRNA or lncRNA was evaluated in relation to the CRC risk and the efficacy of chemotherapy. SNPs in miRNA binding sites of SMUG1 gene affect significantly survival in 5-fluorouracil-treated CRC patients, suggesting the importance of SNPs within miRNA-dependent regulatory regions. Expressions of the specific proteins (mismatch repair, base excision repair) were also assayed for. Functional DNA repair tests have been implemented as biomarkers of the complex phenotype. Multiple biomarkers, covering genetic, epigenetic and functional aspects, may define the phenotypic landscape of the disease and delineate the individual response to the therapy. Functional DNA repair assays reflect the capacity of the organism to cope with a chronic exposure to numerous environmental and dietary genotoxicants and may also be used as predictive markers in cancer therapy
Biography
Pavel Vodicka graduated at the Medical Faculty, Charles University, Prague and in 1986 obtained Ph.D. in biochemistry. He worked as postdoctoral fellow at the Finnish Inst. Occupat. Health, Helsinki, Finland (1987-1990) and as visiting scientist at Karolinska Institute, Huddinge, Sweden (1990-1993). Since 2002 he heads the Dept. Molec. Biol. Cancer, Inst. Exper. Medicine, Acad. Sci., Prague, Czech Republic. Pavel Vodicka has published more than 130 (total IF 552.4, 2650 citations a HI 31) articles. Since 2004, his main research topics are focused on the DNA and chromosomal damage and DNA repair functional tests in humans and on transient biomarkers in the onset of gastrointestinal cancers. In 2012 he edited the Special Issue in Mutagenesis (http://mutage.oxfordjournals.org/content/27/2. toc), entitled Colorectal Cancer-Current Insights into Susceptibility.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords