alexa T-helper 1, T-helper 2, Pro-inflammatory And Anti-inflammatory Cytokines In Tuberculosis | 15097
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Congress on Bacteriology & Infectious Diseases

Abu Salim Mustafa
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.002
Abstract
Cytokines are critical for protection and pathogenesis in tuberculosis. In general, the T-helper (Th)1 and pro-inflammatory cytokines are considered to have a role in protection, and the anti-inflammatory and Th2 cytokines in susceptibility/ pathogenesis of tuberculosis. To better understand the role of cytokines in tuberculosis, we have studied in vitro secretion of the above cytokines from the peripheral blood mononuclear cells (PBMC) of tuberculosis patients (diabetic and non-diabetic) and healthy subjects. PBMC were incubated in vitro with complex mycobacterial antigens and pools of peptides corresponding to 11 M. tuberculosis-specific genomic regions of differences (RDs). The culture supernatants were assayed for the amount of cytokines released after 2 and/or 6 days of incubation. In general, the concentrations of antigen-induced Th2 cytokines were low/undetected and the pro-inflammatory cytokines were non-discriminatory. With respect to Th1 and anti-inflammatory cytokines, the antigens could be divided into three groups; the first with Th1-bias (culture filtrate of M. tuberculosis, RD1, RD5, RD7, RD9, RD10 and RD15), the second with anti-inflammatory-bias (whole bacilli and cell walls of M. tuberculosis, RD12 and RD13), and the third without any bias (M. bovis BCG, RD4, RD6 and RD11). However, among the peptide pools, RD1 peptides induced strongest Th1- bias, and the addition of RD12 and RD13 peptides to PBMC cultures inhibited the RD1-induced Th1-cytokines. The analyses of data for cytokines in diabetic and non-diabetic TB patients showed a shift towards Th2/anti-inflammatory cytokines in diabetic TB patients, which may explain, at least in part, a faster deterioration in their clinical conditions. The work was supported by Kuwait University Research Sector grants MI02/12, MI01/10 and GM01/01 and KFAS grant 2002-1302-04.
Biography
Abu Salim Mustafa has completed Ph.D. in 1979 from the All India Institute of Medical Sciences and postdoctoral studies from the National Institute of Cancer Research, Oslo, and Whitehead Institute for Biomedical Research, Cambridge. He is the director of Research Core Facility at the Health Sciences Centre, Kuwait University. He has published more than 150 papers in reputed journals with more than 5000 citations and h-index of 38. He has served as an editorial board member for 8 journals, invited speaker in 63 conferences and chairman of 18 scientific sessions, member of 15 academic and professional societies, and successfully completed 51 funded research projects.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7