Journal of Clinical & Experimental Pharmacology

Therapeutic effects of methanol extract from Euphorbiae kansui Radix on imiquimod-induced psoriasis

11^th International Conference on Nursing and Immunopharmacology

November 20-21, 2017 Melbourne, Australia

Kwang Woo Hwang

Chung-Ang University College of Pharmacy, Republic of Korea

Scientific Tracks Abstracts: Clin Exp Pharmacol

Abstract:

The roots of Euphorbia kansui Radix which belonging to the family of Euphorbiaceae have been used as a traditional medicine for treating various diseases such as diabetes, ascites, and leukemia. Recently, it has been reported that EKC regulates the differentiation and activity of Th17 cells associated with autoimmune diseases and has been shown to alleviate the symptoms in inflammatory bowel disease models. Imiquimod, a TLR7 / 8 agonists, is approved for the treatment of genital warts and actinic keratosis. Imiquimod is used as an inducer of psoriasis mouse model. In this study, we evaluated the effect of methylene chloride fraction of E. kansui Radix (EKC) in IMQ-induced psoriasis model. It was observed that EKC (5, 10 μg/ml) inhibited the production of IL-17A and IFN-γ effectively in vitro. On the basis of this, EKC was administered to an animal model of psoriasis. The acanthosis and the infiltration of inflammatory cells into dermis were significantly reduced by EKC. EKC also inhibited the expression of IL-17A, IL-22, IL-23, IL-12, and RORγt in the spleen, skin-draining lymph nodes, and skin. Additionally, it was examined whether EKC affects dendritic cells and keratinocytes involved in psoriasis. It was demonstrated that dendritic cell activity is inhibited by EKC but not keratinocyte. In conclusion, EKC ameliorates symptoms of psoriasis by inhibiting the differentiation of Th17 and the activation of the dendritic cell. When EKC was administered at 200 mg/ml, Th17 was suppressed to a similar level as methotrexate, a commonly used treatment for psoriasis. In addition, the relief of skin lesions and immunosuppressive effects caused by high concentration of EKC were superior to those of methotrexate. These effect of EKC are expected to help treat and prevent psoriasis.

Biography :

Kwang Woo Hwang has completed his PhD from Illinois Institute of Technology Chicago Illinois and postdoctoral studies from University of Chicago School of Medicine. He is the associate dean of Research Affair Chung-Ang University. He has published more than 100 papers in reputed journals and has been serving as an editorial board member of 3 publishig groups.