Pharmaceutica Analytica Acta

Thiolated silicone oils as novel skin care agents with enhanced adhesiveness and reinforced occlusivity

5^th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems

March 16-18, 2015 Crowne Plaza, Dubai, UAE

Alexandra Partenhauser

Scientific Tracks Abstracts: Pharm Anal Acta

Abstract:

Aim: The purpose of this study was the evaluation of thiolated silicone oil as novel skin protectant with a prolonged residence time, enhanced barrier function and reinforced occlusivity. Methods: Two silicone thiomers were synthesized with mercaptopropionic acid (MPA) and thioglycolic acid (TGA) as thiol ligands. Adhesion, protection against artificial urine as well as water vapour permeability with both a Payne cup setup and transepidermal water loss (TEWL) measurements on porcine skin were performed. Results: Silicone conjugates showed pronounced substantivity on skin with 39.2 ? 6.7 % and 22.1?6.3 % remaining silicone after 8 h for silicone-MPA and silicone-TGA, respectively, whereas unmodified silicone oil and dimethicone were no longer detectable. Especially silicone- MPA strikingly shielded skin against artificial urine penetration for up to 6 h and showed a reduced TEWL by two third in comparison to control. Conclusion: Thiolation of silicone oils leads to enhanced skin adhesiveness due to disulfide crosslinking, which is a major advantage compared to commonly used silicones, such as dimethicone. Depending on the thiol ligand, various degrees of occlusivity can be achieved. Thiolated silicone oils thus provide a protective layer and improve skin moisturization. Pharmaceutical targets might be hypertrophic scars and keloids, neurodermatitis, psoriasis as well as atopic, allergic or irritant contact dermatitis.

Biography :

Alexandra Partenhauser is writing her PhD thesis on polymeric drug delivery systems under the supervision of Prof. Bernkop-Schnurch in Innsbruck, Austria and has already published one paper in a well reputed journal within her first year. She previously finished both her Master of Pharmaceutical Sciences and studies of Pharmacy in Munich, Germany, where she was part of a project on an ocular sustained delivery system in the research group of Prof. Winter for her Master thesis.