alexa Thioredoxin-interacting (TXNIP) Protein Regulates The Differentiation Of Erythroid Precursors
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Conference on Hematology & Blood Disorders
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Volker Blank
ScientificTracks Abstracts: J Blood Disorders Transf
DOI: 10.4172/2155-9864.S1.006
Thioredoxin-interacting protein (TXNIP) is involved in various cellular processes includingredox control, metabolism, differentiation, growth and apoptosis. With respect tohematopoiesis, TXNIP has been shown to play roles in natural killer cells, dendritic cells andhematopoietic stem cells. Our study investigates the role of TXNIP in erythropoiesis. Weobserved a rapid and significant increase of TXNIP transcript and protein levels in mouseerythroleukemia (MEL) cells treated with DMSO or HMBA, inducers of erythroiddifferentiation. The upregulation of TXNIP was not abrogated by addition of the antioxidantN-acetylcysteine. The increase of TXNIP expression was confirmed in another model oferythroid differentiation, G1E-ER cells, which undergo differentiation upon activation of theGATA1 transcription factor. In addition, we showed that TXNIP levels are inducedfollowing inhibition of p38 or JNK MAPKs. We also observed an increase in iron uptakeand a decrease in transferrin receptor protein upon TXNIP overexpression, suggesting a rolein iron homeostasis. In vivo , flow cytometry analysis of cells from TXNIP-/- mice revealed anew phenotype of impaired terminal erythropoiesis in the spleen, characterized by a partialblock between basophilic and late basophilic/polychromatic erythroblasts. Based on our data,TXNIP emerges as a novel regulator of terminal erythroid differentiation.
Volker Blank has completed his Doctorate in Immunology at the Institut Pasteur/ Universityof Paris VI. He is now a Senior Investigator at the Lady Davis Institute for Medical Researchand an Associate Professor at McGill University. His research program focuses onhematopoiesis and cancer.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version