alexa Through The Looking Glass - New Views Of Steroid Receptor Actions
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference on Endocrinology
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

S Stoney Simons Jr
Keynote: Endocrinol Metab Synd
DOI: 10.4172/2161-1017.S1.004
Abstract
A common but unexplained observation regarding steroid receptor-regulated gene induction is that the maximal activity (Amax) and steroid concentration required for half-maximal activity (EC50) are not fixed parameters for a specific steroid. Instead, changing concentrations of factors can modulate the values of Amax and EC50, even for a selected gene in a given cell line. Such phenomena are essential for differential control of gene expression during development, differentiation, and homeostasis. We have developed, in collaboration with Dr. Carson Chow (NIH), an experimentally supported mathematical model of steroid hormone action that not only accounts for these changes in Amax and EC50 but also utilizes the changes to obtain previously unobtainable information about the mechanism of action of the modulatory factors. The basis of this model is that the dose-response curve for product formation follows Michaelis-Menten kinetics to give a first-order Hill plot. A competition assay has been developed from this model that determines both the relative positioning in the overall reaction sequence, and the kinetically determined mechanism of action, of any two competing factors. As examples of the utility of this competition assay, an analysis of new modulatory factors affecting both glucocorticoid receptor-mediated gene induction and repression will be presented. This information not only establishes an internally consistent framework for categorizing factor actions but also permits a clinically relevant, more targeted approach to modifying the expression of steroid-regulated target genes that should be accompanied by fewer side effects.
Biography
Simons received his PhD from Harvard University. After a postdoctoral fellowship at University of California, SF, he moved to the NIH and became Chief of the Steroid Hormones Section in 1985. He has published over 150 papers, and has 5 patents, in the field of the mechanism of steroid hormone action, with an emphasis on the role of transcription cofactors. He has served on review boards of numerous grant review panels and journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords