alexa Time-course Measurements Of Drug Concentrations In Hair And Nails After Single Administrations Of Pharmaceutical Products By LC/MS/MS
ISSN: 2157-7064

Journal of Chromatography & Separation Techniques
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Mass Spectrometry
October 10-11, 2016 Kuala Lumpur, Malaysia

Kenji Kuwayama
National Research Institute of Police Science, Japan
Posters & Accepted Abstracts: J Chromatogr Sep Tech
DOI: 10.4172/2157-7064.C1.023
Abstract
In forensic drug testing, hair and nails are often used to prove chronic intake of drugs over several months. The aim of this study was to evaluate the effectiveness of drug testing using hair and nails and the feasibility of determining when drugs were ingested by measuring the time courses of drug concentrations in hair and toenails after single administrations of various drugs. Hair and toenails were collected at predetermined intervals up to 12 months after administrations of eight drugs to healthy subjects. Micropulverized extraction using a stainless steel bullet was used for simple homogenization of the matrices and effective drug extraction. The concentrations of the administered drugs and their main metabolites in hair segments and nails collected at every sampling time were measured using liquid chromatography/tandem mass spectrometry (LC/MS/MS). The time courses of drug concentrations were compared between hair and nails. Acidic compounds such as ibuprofen and its metabolites were not detected in both specimens. Neutral and weakly acidic compounds such as allyl isopropyl acetylurea and acetaminophen were detected in nails more frequently than in hair. For fexofenadine, a zwitterionic compound, and for most basic drugs, the maximum concentrations in hair segments tended to be higher than those in nails. The hair segments showing the maximum concentrations varied between drugs, samples, and subjects. Drug concentrations in hair segments are greatly depended on the selection of the hair. Careful interpretation of analytical results is required to predict the time of drug intake.
Biography

Kenji Kuwayama (PhD) is a Researcher of National Research Institute of Police Science, Japan. He did his Master’s in Drug Analysis and Forensic Toxicology. He has published more than 25 papers in reputed journals.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords