alexa Tityus Serrulatus Venom Induces Inflammation By Mechanism Dependent On Lipid Mediator Release And Lipid Bodies? Formation | 21581
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Summit on Toxicology & Applied Pharmacology
October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

L?cia Helena Faccioli
ScientificTracks Abstracts: J Clin Toxicol
DOI: 10.4172/2161-0495.S1.012
Abstract
T ityus serrulatus venom (TsV) induces a severe systemic inflammatory reaction that can result in death. For this reason it is very important to understand the mechanisms responsible for the induction of inflammatory mediators release after envenomation. It was demonstrated that TLR2, TLR4 and CD14 receptors sense TsV and its major component, toxin 1 (Ts1), to mediate eicosanoids release and inflammation. Eicosanoids such as LTB4 and PGE2 are metabolites from arachidonic acid (AA) released from cell membranes after phospholipase A 2 (PLA 2 ) action. Consequently, the intracellular signaling cascade leading to production of eicosanoids, and the participation of lipid bodies (LBs) as functional organelles for LTB 4 and PGE 2 synthesis induced by TsV was investigated. Data revealed that TsV induced LBs formation on macrophages by mechanisms dependent on TLR 2 and TLR 4 recognition, and activation of the nuclear receptor PPARγ. Based on the data, it was suggested that during envenomation, LBs are the functional organelle for eicosanoids production andinduction of inflammatory reaction triggered by TsV. Finally, the term venom-associated molecular pattern (VAMP) was suggested to indicate molecules that are introduced into the host by stings and are recognized by PRRs, resulting in inflammation
Biography
L?cia Helena Faccioli has completed her PhD from S?o Paulo University (USP) and Postdoctoral studies from National Heart and Lung Institute, London in 1989- 1990. She is full Professor in Immunology and Class 1A Researcher for the National Council for Scientific and Technological Development, since 2007; Head of the Laboratory of Inflammation and Immunology at School of Pharmaceutical Sciences of Ribeirao Preto-USP and member of Postgraduate Committee on Basic and Applied Immunology, at Ribeir?o Preto School of Medicine-USP. She has published more than 130 papers in reputed journals and serving as an editorial board member of repute
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version