alexa TMEM166 Knockdown Attenuates Ischemic-induced Neuronal Autophagy Via MTOR Pathway In Mice
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Neurology & Therapeutics
September 08-10, 2014 Hilton Philadelphia Airport, USA

Changman Zhou, Chutong Lin, Yue Hou and Li Li
ScientificTracks Abstracts: J Neurol Neurophysiol
DOI: 10.4172/2155-9562.S1.017
Abstract
Transmembrane protein 166 (TMEM166), also known as FAM176A, is located on chromosome 2p12. Recent studies have shown that over-expression of TMEM166 markedly inhibits the proliferation of tumor cells and induces both cell autophagy and apoptosis. It was also found had a significant increase after MCAO. However, the role of TMEM166 involved in this process is still unknown. To determine the role of TMEM166 following MCAO injury, 156 male C57 mice were randomly divided into 4 groups: Sham, MCAO (wild type), MCAO (TMEM166 knockout), MCAO+ Rapamycin (mTOR inhibitor, ip, 0.5 ng in 0.5 ul 0.1% DMSO, 20 min before MCAO), MCAO+ shTSC2 (mTOR activator, i.c.v, 5 μl immediately after MCAO). TTC, neurological scores, mortality rate, brain water content, TUNEL staining, western blot and immunohistochemistry (Beclin-1, LC-, mTOR, p-mTOR, p70s6k, p-p70s6k) were conducted 24 h following MCAO. The results show that TMEM166 knockdown inhibits autophagy and improves brain injury following MCAO in mice. Compared with untreatd c57 mince, rapamycin treated mice shows downregulation of mTOR and upregulation of TMEM166 by western blot and immunohistochemistry. Treatment with TSC2 shRNA increases the expression of mTOR and decreases the expression of TMEM166.
Biography
Changman Zhou is Professor in Department of Anatomy and Histology at Peking University Health Science Center, China. Currently, he is the Vice-President and General Secretary of Chinese Society of Anatomical Sciences (CSAS). His current research focus is preclinical translational research related to the neuronal regeneration and neurobiology of diseases such as stroke. He published more than 120 international papers and many book chapters. He is currently on the Editorial Boards of Clinical Anatomical, Anatomical Record, Anatomy & Cell Biology and Vice Editor-in- Chief of Acta Anatomica Sinica
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords