alexa TMP1 Significantly Suppresses Mammary Tumor Metastasis Via Inhibition Of Granulocytic Myeloidderived Suppressor Cell Differentiation
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Ning-Sun Yang, Sheng-Yen Lin, Ying-Chu Wang, Chun-Wen Lan, Wen-Chin Yang, Pei-Wen Hsiao and Wen-Chi Wei
Accepted Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.019
Abstract
M yeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells including immature granulocytes, macrophages, and dendritic cells that expand extensively during cancer, inflammation and infection. MDSCs are increasingly recognized as having a crucial role in protecting tumor cells from immune surveillance by suppressing anti-tumor immunity. This study aimed to investigate the immune-regulatory and antitumor activities of TMP1 on MDSC expansion and tumor metastasis. The results showed that TMP1 effectively suppressed mammary 4T1 tumor metastasis and increased mouse survival in a mammary tumor resection mouse model. In addition, TMP1 significantly decreased tumor- induced splenomegaly and the number of granulocytic MDSCs in test mice. In ex vivo cell culture assays, TMP1 did not decrease the level of granulocyte colony stimulating factor (G-CSF, a key cytokine for granulocytic MDSC differentiation) produced by tumor tissue, tumor associated stromal cells and 4T1 cells. However, TMP1 significantly inhibited granulocyte- macrophage colony stimulating factor (GM-CSF) or G-CSF-induced MDSC differentiation from bone marrow cells. TMP1 also strongly inhibited GM-CSF-induced expression level of G-CSF receptor in bone marrow cells. Taken together, our results suggest that TMP1 significantly suppresses mammary tumor metastasis via inhibition of granulocytic MDSC differentiation.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords