Journal of Clinical & Experimental Dermatology Research
Open Access

To evaluate the efficacy of Non Cultured Extracted Hair Follicle Outer Root Sheath Cell Suspension in cases of Stable Vitiligo

10^th Asia-Pacific Dermatology Conference

November 28-29, 2016 Melbourne, Australia

Akshi Bansal, Leelavathy B, Shilpa K, Harish Prasad, Revathi T.N, Asha G.S, Eswari L, Divya G, Shwetha S, Lakshmi D.V

Department of Dermatology, Bangalore Medical College and Research Institute, India

Posters & Accepted Abstracts: J Clin Exp Dermatol Res

Abstract :

Background: Vitiligo is an acquired disorder of pigmentation caused by loss of epidermal melanocytes. Current non cultured cell based transplantation therapies largely involve shave skin biopsy for preparation of melanocyte suspension. Follicular cell suspension (FCS) is a novel technique based on findings that hair follicle not only has higher proportion of melanocytes but also their precursor stem cells, which have not been recognized in epidermis. Materials and Method : 30 patients with vitiligo, stable for atleast 6 months were included in this study. Hair follicles were extracted by Follicular Unit Extraction method from occipital scalp and were incubated in Trypsin-EDTA to separate outer root sheath cells. The suspension was centrifuged to obtain a pellet which was resuspended and applied to dermabraded recipient area. Results: Overall, 17 out of 30 patients showed>75% pigmentation. 3 patients showed<25% pigmentation (with all three being>50 years of age). The donor site healing was considered as excellent by all the patients with no report of any perceptible change,post healing. Conclusion: Non cultured FCS can be a useful transplantation method for vitiligo with added advantage of absence of donor site scarring or pigmentation as is the case inepidermal cell suspension technique.

Biography :

Email: akshiibansal111@gmail.com