Reach Us +44-1647-403003
Total Expression Of Human Leucocyte Antigen-G And Toll-like Receptor-9 In B-cell Chronic Lymphocytic Leukemia Patients: Relationship To Prognostic Markers | 105115
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Total expression of human leucocyte antigen-G and Toll-like receptor-9 in B-cell chronic lymphocytic leukemia patients: Relationship to prognostic markers

32nd Euro Congress on Cancer Science & Therapy

Hala Kassem Ahmed Said Sultan

Medical Research Institute, Alexandria University , Egypt

ScientificTracks Abstracts: J Cancer Sci Ther

DOI: 10.4172/1948-5956-C1-159

Introduction: In CLL patients, immune escape mechanisms allow leukemia cells to proliferate and expand. Human leukocyte antigen G (HLA-G) is a further strategy adopted by CLL cells to evade immune defenses and to create protected niches where to grow and expand. Toll-like receptors (TLRs) represent major agents of innate immunity and initiators of adaptive immunity. It has been suggested that the stimulation of TLRs expressed on CLL cells could increase immunogenicity of tumor cells and thus potentially contribute to the induction of tumor-specific immune response. We study the total expression of HLA-G and TLR-9 in CLL patients, evaluating their relationships with other well established clinical and possible laboratory prognostic markers.

Methods: This study enrolled 40 CLL patients selected from the Hematology Department of the medical research institute and Alexandria Main Hospital. In addition, to 20 healthy subjects matched by age and sex.

Results: In CLL patients, HLA-G showed significant negative correlation to TLR-9 and both of them showed significant association with disease stage and prognostic index.

Conclusion: This study concluded that expression of HLA-G and TLR-9 could have a prognostic value in CLL patients; the higher the HLA-G expression, the lower the TLR-9 expression, the worst the outcome. Use of HLA-G and/or TLR-9 as markers for new targeted therapy in CLL could be valuable.

Hala K. Sultan ; professor of hematology, graduated from Alexandria University in 1984 , She obtained her master degree in Clinical Hematology from Faculty of Medicine at the same University in 1990 and earned her MD degree in benign and malignant Hematology from Hematology department , Medical Research Institute in 1998. She has been working since then as a Hematologist in the same department, currently the Head of the department since June 2018. She has been involved in teaching & clinical research, supervised more than 25 master and MD theses and she has about 20 publications in various international and national journals.

E-mail: [email protected]


Relevant Topics