alexa Towards Molecular Medicine Approaches In Hereditary Autoinflammation And The Inflammasome
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Proteomics & Bioinformatics
July 15-17, 2013 Courtyard by Marriott Philadelphia Downtown, USA

Sinem Nalbantoglu
ScientificTracks Abstracts: J Proteomics Bioinform
DOI: 10.4172/0974-276X.S1.067
Abstract
Hereditary autoinflammatory diseases are heterogenous group of disorders characterized by seemingly unprovoked fever and localized recurrent episodes of excess systemic inflammation without any pathogens stimuli. Unlike autoimmune disorders, autoinflammatory disorders lack the production of high-titer autoantibodies or antigen-specific T cells. The most important determinants of autoinflammatory diseases which are named also as ?hereditary periodic fevers? are abdominal pain and fever characterized with acute and usually short attacks of serosal, synovial and cutaneous inflammation. These disorders are caused by primary dysfunction of the innate immune system, without evidence of adaptive immune dysregulation. The protein products of the genes which are associated with these disorders are known to control innate immunity and apoptosis. Role of pyrin (PyD) and/or caspase recruitment domain (CARD) containing regulator and adaptor proteins in inflammation, apoptosis, and innate immunity has been previously outlined. The inflammasome is composed of intracellular receptor NALP and ASC adapter which stimulates caspase-1 activation. Mutations in the NALP3 inflammasome and NLR cause autoinflammatory syndromes by increased inflammasome activity responsible for uncontrolled IL-1β production. In this communication, we have documented molecular analysis data of the studied patient populations with autoinflammatory disorders, and our research activities conducted on autoinflammatory disease genes. Moreover, current work also underlined the critical significance of molecular diagnosis which refers to detailed mutation screening of autoinflammatory disease genes in particular for mutation negative or asymptomatic individuals among at-risk populations. Since there is still way in understanding and exploring the undefined periodic syndromes, further studies are required to discover novel inflammatory pathways.
Biography
Sinem Nalbantoglu has completed her Ph.D at the age of 27 years from Ege University and postdoctoral studies from Ege University School of Medicine. She is now working as assistant professor in Nisantasi University. She has been publishing papers in reputed medical journals and serving as referee in many peer-reviewed journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version