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Toxicological Assessment Of The Aqueous Extract Of The Leaves Of Moringa Oleifera And Caulis Bambusae In Rabbit | 5839
ISSN: 2161-0495

Journal of Clinical Toxicology
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Toxicological assessment of the aqueous extract of the leaves of Moringa oleifera and Caulis bambusae in rabbit

International Toxicology Summit & Expo

Chinwe Christy Isitua and Isaiah Nnanna Ibeh

ScientificTracks Abstracts: J Clinic Toxicol

DOI: 10.4172/2161-0495.S1.002

T welve age-matched healthy adult male Chinchilla rabbits (2.0 + 0.5 kg BW) were divided into three equal groups (two treatment and one control groups). The treatment groups were given 2.5 ml and 5.0 ml of aqueous extract of the leaves of Moringa oleifera and Caulis bambusae by oral intubation, while the control group received 5.0 ml of the vehicle of extraction (sterile distilled water) and examined for 30 days. The effect of the leave extracts on the haematological parameters, selected liver enzymes, insulin level and body weights of the affected rabbits were analyzed. There were significant increases in CD4 Cells (P < 0.01), neutrophils (P < 0.05) and a significant decrease in lymphocytes (P < 0.05). There was an enhancement in the activities of alkaline phosphatase, aspartate transaminase and alanine transaminase in rabbits exposed to 2.5 ml of the extract. There was no significant difference in the histology of major organs, weights and the physical and behavioral pattern of both test and control rabbits

Chinwe Christy Isitua obtained a B.Sc. (Hons.) degree in Microbiology with a Second Class Upper Division in 2002 and thereafter obtained a Masters and PhD degrees in Environmental & Public Health Microbiology and Food & Industrial Microbiology respectively in 2006 and 2012 all from the University of Benin, Nigeria. She acquired a Postgraduate Diploma in Education degree from the National Teachers? Institute, Kaduna in 2011. She joined the University of Benin as an Assistant Lecturer in 2007 and currently holds the position of Lecturer 1 in the Department of Microbiology. Her areas of interests are environmental toxins (mycotoxins), immunomodulation, food toxicology and ethnomedicine. She has over 10 publications in reputable local and international journals. She is a member of American Society of Microbiology (ASM), Nigerian Society of Microbiology (NSM) and West African Society of Toxicology (WASOT)