alexa Toxicological Assessment Of The Mainstream Aerosol Of A Carbon Heated Tobacco Product In Sprague-Dawley Rats: A 90-day Sub-chronic Inhalation Study
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

10TH Asia-Pacific Pharma Congress
May 08-10, 2017 Singapore

Phillips B W, Ho J, Sciuscio D, Veljkovic E, Lebrun S, Kogel U, Vuillaume G, Leroy P, Hoeng J, Peitsch M C and Vanscheeuwijck P
Philip Morris International Research Laboratories Pte. Ltd., Singapore
Philip Morris Products S A, Switzerland
Posters & Accepted Abstracts: J Pharma Care Health Sys
DOI: 10.4172/2376-0419-C1-021
Abstract
CHTP (carbon heated tobacco product) 1.2 is a potential modified risk tobacco product in which the tobacco plug in a specially designed stick is heated to ≤ 300°C using a carbon heat source. The operating temperature is below the combustion temperature of tobacco, resulting in generation of aerosol with significant reduction of harmful and potentially harmful constituents compared with cigarette smoke. The toxicity of CHTP 1.2 was characterized in a 90-day sub-chronic inhalation study according to the OECD 413 testing guidelines. Sprague-Dawley rats were exposed for 6 hours per day, 5 days per week for at least 13 weeks to filtered air (control), mainstream smoke of reference cigarette 3R4F at 23 μg nicotine/L, or aerosol of CHTP 1.2 at three target concentrations of 15, 23 and 50 μg nicotine/L, respectively. Additional animals from control and CHTP 1.2 high exposed groups were included to observe reversibility of toxicity over a period of 42 days after the exposure. Reduction in respiratory minute volume and frequency typically observed in 3R4F-exposed group was less pronounced in animals breathing CHTP 1.2 aerosol. The number of inflammatory cells and levels of excreted pro-inflammatory cytokines in bronchoalveolar lavage fluid of animals exposed to CHTP 1.2 were lower than in the 3R4F-exposed group. Clinical pathological changes such as higher blood neutrophil counts, elevated liver enzymes and decrease of cholesterol and glucose levels were observed in 3R4F and lesser extent in CHTP 1.2 high groups, compared with control. Microscopic findings in respiratory tract organs including epithelial cell hyperplasia and squamous metaplasia were reduced in CHTP 1.2 as compared with 3R4F-exposed group. In summary, the results indicate that the inhalation of aerosol from CHTP 1.2 caused minor effects in rats mainly attributed to nicotine, and the effects on respiratory tract organs were much lower compared with those from 3R4F reference cigarette.
Biography

Initially trained as a cellular and molecular biologist, Blaine began his scientific career studying the potential of differentiated embryonic stem cells as cellular replacement therapies in a biotechnology start-up company. This led to a journey spanning 3 continents working in the pharmaceutical and the tobacco industries in research and development departments focusing on assay development and drug discovery, as well as inhalation toxicology.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords