Clinical Microbiology: Open Access

Toxoplasmosis in immunocompetent and immunocompromised population of Constanta, Romania

3^rd International Conference on Clinical Microbiology & Microbial Genomics

September 24-26, 2014 Valencia Convention Centre, Spain

Irina Magdalena Dumitru, Roxana Carmen Cernat, Corina Pascu and Sorin Rugina

Scientific Tracks Abstracts: Clin Microbial

Abstract:

Introduction: Toxoplasmosis, an infection with a worldwide distribution, is caused by the intracellular protozoan parasite, Toxoplasma gondii. Material and methods: A total of 386 adult patients diagnosed with toxoplasmosis in the Infectious Diseases Hospital in the last 5 years were analyzed. Results: Of these patients, 85% were from urban area, 77% female; majority aged 30-49 years. 3% were diagnosed with HIV infection (12 patients), in three of these patients, toxoplasmosis was the primary clinical manifestation. The most common clinical manifestation in non HIV infected patients was painless cervical adenopathy (102 patients), followed by flulike symptoms and generalized lymphadenopathy (6 patients), retroperitoneal and mesenteric lymphadenopathy with abdominal pain (8 patients), seizures, persistent headache (32 patients), retinochoroiditis (12 patients), pulmonary involvement (4 patients), cerebral toxoplasmosis (mass lesions) only in a female with chronic hepatitis B and non Hodgkin lymphoma. 56 pregnant women (5 with acute infection and 51 with chronic infection were followed during pregnancy), 43 patients had associated infection with Toxocara and were presented to the hospital for itchy rash. No clinical symptoms were observed in other immunocompetent patients, toxoplasma infection was diagnosed incidentally. In HIV infected patients cerebral toxoplasmosis (toxoplasmic encephalitis, with or without focal CNS lesions) prevailed; only one patient presented generalized lymphadenopathy and pulmonary involvement. Conclusion: Reporting the number of cases of toxoplasma infection in Constanta population (254.693 inhabitans), we obtain a prevalence of 151.5 cases/100.000 inhabitants. Most patients were female and their supervision is required for possible implications in pregnancy. We believe that toxoplasma infection is under diagnosed in our county.

Biography :

Irina Magdalena Dumitru is MD, PhD, Associate Professor in the ?Ovidius? University, Constanta, Faculty of Medicine, Senior Specialist, Director of research and development (2006-2010). He is the President of the Romanian Association of Parasitology, Constanta. In recent years he focused on the parasitological, tropical diseases, chronic hepatitis and HIV/AIDS research. Presently, he is working in NCP Health Romania for Horizon 2020 program. He is involved in many research projects and has published numerous scientific articles.