alexa Tracking Anti-tumor Drugs: Ruthenium(II)-cyclopentadienyl Complexes As Promising Agents
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Medicinal Chemistry & Computer Aided Drug Designing
December 08-10, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

M Helena Garcia, T?nia S Morais, Andreia Valente and Fernanda Marques
ScientificTracks Abstracts: Med Chem
DOI: 10.4172/2161-0444.S1.011
Abstract
Ruthenium complexes hold great potential as alternatives in cancer treatment and have been the most widely studied nonplatinum anticancer drug candidate. During the recent years our group has been involved in the synthesis of new half sandwich ?Ru(η5-C5H5)? derived compounds, of which cytotoxicity was found, in most of the cases, better than that of cisplatin against several cancer cell lines of typically low, medium and high resistance to metallodrugs, namely ovarian, breast, colon and prostate human tumors (A2780, MCF7, MDAMB231, HT29 and PC3 cell lines). The therapeutic effect of one of these compounds was evaluated in an orthotopic triple negative breast cancer (TNBC) mouse model and has demonstrated the in vivo capacity to suppress tumor growth, not presenting the severe side-effects of other non-targeted chemotherapeutic agents. Moreover, autopsy of the animals did not show any metastasis in the lungs or other organs. In this presentation, we present an overview of our most recent progress in this field, highlighting our chief results. Thus, a new generation of compounds will be presented, based in the fragment ?Ru(η5-C5H5)?with appended molecules, in order to optimize our best results already obtained, having also in view the recognition by cancer cells, for target therapy. Finally, studies to understand the pharmacokinetic and the involved mechanisms of action will also be presented.
Biography
M Helena Garcia is Associate Professor with ?Habilitation? at University of Lisbon. Her scientific areas of research have been mainly centered in synthesis of organometallic compounds in view to potential applications with benefit to the society. She has authored over eighty publications and several book chapters. She has been leader of several national and European funded scientific research projects and is Member of the ?Division of Organometallic Chemistry? of European Association for Chemical and Molecular Sciences, as delegate of Portuguese Chemical Society, since 1992. She is Coordinator of the International Office at Faculty of Sciences, University of Lisbon.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version