alexa Transcription Level Of The Suppressors Of Cytokine Signaling 1 And 3 In Patients With Multiple Sclerosis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Virginia Sede?o-Monge, Ra?l Arcega-Revilla, Emmanuel Rojas Morales, Gerardo Santos-L?pez, Juan Carlos Perez-Garc?a, Francisca Sosa Jurado, Ver?nica Vallejo-Ruiz, Casandra Lucrecia Solis Morales, Salvador Aguilar-Rosas and Julio R Reyes-Leyva
Posters: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.018
Abstract
Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Some experimental observations suggest that IFN- γ and other proinflammatory cytokines have an important role in the pathogenesis of MS. The suppressors of cytokine signaling (SOCS) negatively regulate the proinflammatory cytokine- induced response, moderating consequently the immune response. The aim of the study was to quantify SOCS1 and SOCS3 transcription in peripheral blood leucocytes of patients with MS by quantitative real-time reverse transcription-PCR and analyze their correlation with disease progression. Values were analyzed by means of the comparative method 2-ΔΔCT (fold difference). Forty MS patients and twenty six healthy individuals were included; all persons were neurologically evaluated through the Expanded Disability Status Scale (EDSS). SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08?0.02 vs. 1.02?0.23; p=0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76?0.66 vs. 1.03?0.27; p=0.0008). A weak correlation between the patients neurological status (EDSS values) and either SOCS1 or SOCS3 expression was found (for SOCS1 r=-0.11 p= 0.5; for SOCS3 r= -0.2 p=0.2) and slight negative correlation between SOCS3 and SOCS1 expression was found (Spearman?s r=-0.57; p=0.0003) in MS patients. An important contribution of our study is that the ratio SOCS1:SOCS3 showed a strong and significant association between both genes in all samples, this can be a reflection of the fine balance between different members of SOCS family.
Biography
Virginia Sede?o Monge completed his PhD in Ciencias Microbiol?gicas in 2010 from Universidad Aut?noma de Puebla. She is Professor of Physiology in the Universidad Popular Aut?noma del Estado de Puebla School of Medicine. She is member of Sistema Nacional de investigadores (SNI) of M?xico since 2012, and is currently working on transcription genes with real time PCR.
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