Reach Us +1-504-608-2390
Transcription Level Of The Suppressors Of Cytokine Signaling 1 And 3 In Patients With Multiple Sclerosis | 19653
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference and Exhibition on Clinical & Cellular Immunology

Virginia Sede?o-Monge, Ra?l Arcega-Revilla, Emmanuel Rojas Morales, Gerardo Santos-L?pez, Juan Carlos Perez-Garc?a, Francisca Sosa Jurado, Ver?nica Vallejo-Ruiz, Casandra Lucrecia Solis Morales, Salvador Aguilar-Rosas and Julio R Reyes-Leyva
Posters: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.018
Multiple sclerosis (MS) is an autoimmune disease characterized by a triad of inflammation, demyelination and gliosis. Some experimental observations suggest that IFN- γ and other proinflammatory cytokines have an important role in the pathogenesis of MS. The suppressors of cytokine signaling (SOCS) negatively regulate the proinflammatory cytokine- induced response, moderating consequently the immune response. The aim of the study was to quantify SOCS1 and SOCS3 transcription in peripheral blood leucocytes of patients with MS by quantitative real-time reverse transcription-PCR and analyze their correlation with disease progression. Values were analyzed by means of the comparative method 2-ΔΔCT (fold difference). Forty MS patients and twenty six healthy individuals were included; all persons were neurologically evaluated through the Expanded Disability Status Scale (EDSS). SOCS1 transcription decreased significantly in MS patients compared with neurologically healthy persons (0.08?0.02 vs. 1.02?0.23; p=0.0001); while SOCS3 transcription increased in MS patients compared with controls (2.76?0.66 vs. 1.03?0.27; p=0.0008). A weak correlation between the patients neurological status (EDSS values) and either SOCS1 or SOCS3 expression was found (for SOCS1 r=-0.11 p= 0.5; for SOCS3 r= -0.2 p=0.2) and slight negative correlation between SOCS3 and SOCS1 expression was found (Spearman?s r=-0.57; p=0.0003) in MS patients. An important contribution of our study is that the ratio SOCS1:SOCS3 showed a strong and significant association between both genes in all samples, this can be a reflection of the fine balance between different members of SOCS family.
Virginia Sede?o Monge completed his PhD in Ciencias Microbiol?gicas in 2010 from Universidad Aut?noma de Puebla. She is Professor of Physiology in the Universidad Popular Aut?noma del Estado de Puebla School of Medicine. She is member of Sistema Nacional de investigadores (SNI) of M?xico since 2012, and is currently working on transcription genes with real time PCR.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version