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Transdermal drug delivery route is a potential route for delivering drugs, but the main drawback is penetration through skin.
To overcome the stratum corneum barrier vesicle formulations have been used as skin delivery systems. Invasomes are novel
elastic vesicles composed of phosphatidylcholine, ethanol and terpene. They enhance permeation by penetrating intact into
the stratum corneum through low penetration resistance channels or the vesicular materials interact with intracellular lipids,
disrupting/disorganizing the lipid lamellae thus forming penetration channels for drug molecules to penetrate. Finasteride, an
azasteroid used in the treatment of benign prostatic hyperplasia and male pattern baldness (alopecia) is administered at doses
1mg and 5mg daily. Its low molecular weight 372.6 daltons, half-life (6hrs in individuals less than 60yrs old), bioavailability (63%)
and log P (3.03) are ideal physico-chemical properties for transdermal delivery. Taguchi robust design is an experimental design
using mathematical and statistical techniques for characterizing complicated process. Finasteride invasomes were formulated and
optimized by Taguchi robust design. Two factor three level design with terpenes (limonene, carvone and nerolidol) were selected
to construct Taguchi L9 orthogonal array experimental design for formulation of invasomes. Vesicle size, entrapment efficiency,
zeta potential, permeation studies, stability studies and histopathology studies were evaluated. Limonene 0.5% which enhanced
permeation by 21.17 fold over aqueous solution was optimized. Permeation studies and histopathology studies indicated
invasomes as a novel lipid carrier for transdermal delivery.
Prasanthi domaraju is pursuing PhD in pharmaceutics in Jawaharlal Nehru technological university, Hyderabad, India. She is working as an assistant
professor (pharmaceutics) in G.Pulla reddy college of pharmacy, Hyderabad, India. She has 9 years of teaching experience and has published 7
articles in international journals and presented in nearly 10 national and international conferences. She is Life member of APTI.
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