alexa
Reach Us +1-217-403-9671
Transdermal Delivery Of Finasteride Invasomes Using Taguchi Robust Design Method | 7450
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Transdermal delivery of finasteride invasomes using taguchi robust design method

2nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

Prasanthi.D

Posters: Pharmaceut Reg Affairs

DOI: 10.4172/2167-7689.S1.007

Abstract
Transdermal drug delivery route is a potential route for delivering drugs, but the main drawback is penetration through skin. To overcome the stratum corneum barrier vesicle formulations have been used as skin delivery systems. Invasomes are novel elastic vesicles composed of phosphatidylcholine, ethanol and terpene. They enhance permeation by penetrating intact into the stratum corneum through low penetration resistance channels or the vesicular materials interact with intracellular lipids, disrupting/disorganizing the lipid lamellae thus forming penetration channels for drug molecules to penetrate. Finasteride, an azasteroid used in the treatment of benign prostatic hyperplasia and male pattern baldness (alopecia) is administered at doses 1mg and 5mg daily. Its low molecular weight 372.6 daltons, half-life (6hrs in individuals less than 60yrs old), bioavailability (63%) and log P (3.03) are ideal physico-chemical properties for transdermal delivery. Taguchi robust design is an experimental design using mathematical and statistical techniques for characterizing complicated process. Finasteride invasomes were formulated and optimized by Taguchi robust design. Two factor three level design with terpenes (limonene, carvone and nerolidol) were selected to construct Taguchi L9 orthogonal array experimental design for formulation of invasomes. Vesicle size, entrapment efficiency, zeta potential, permeation studies, stability studies and histopathology studies were evaluated. Limonene 0.5% which enhanced permeation by 21.17 fold over aqueous solution was optimized. Permeation studies and histopathology studies indicated invasomes as a novel lipid carrier for transdermal delivery.
Biography
Prasanthi domaraju is pursuing PhD in pharmaceutics in Jawaharlal Nehru technological university, Hyderabad, India. She is working as an assistant professor (pharmaceutics) in G.Pulla reddy college of pharmacy, Hyderabad, India. She has 9 years of teaching experience and has published 7 articles in international journals and presented in nearly 10 national and international conferences. She is Life member of APTI.
Top