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Transplantation Of Human Adipose-derived Mesenchymal Stem Cell With PCL Skin Scaffold To Burn Wound In Nonimmunocompromised Guinea Pigs | 5154
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Transplantation of human adipose-derived mesenchymal stem cell with PCL skin scaffold to burn wound in nonimmunocompromised Guinea pigs

International Conference & Exhibition on Cell Science & Stem Cell Research

Seyed Jafar Hashemian and Kamran As'adi

ScientificTracks Abstracts: J Cell Sci Ther

DOI: 10.4172/2157-7013.S1.02

Patients with massive burns have morbidity and mortality closely related to the limited availability of donor sites. Autograft ing has been considered as a gold standard treatment for excised burn wounds. However, in patients with extensive burns , limited availablity of donor sites for harvesting skin graft may signifi cantly aff ect its utilization. Skin tissue engineering by providing a reliable skin substitute, can be considered as an optimal alternative of human skin graft s for coverage of massive burns. Th is area of expertise has been developed to repair and regenerate damaged organs using a combination of cells, biomaterials and growth factors. Nanofi bers are submicron fi brils that mimic the extracellular matrix, promoting cellular adhesion, proliferation, and migration. Polycaprolactone (PCL) nanofi bers were electrospun using standard techniques could be use as skin scaff old. Human adipose-derived mesenchymal stem cells (HAMSCs) are well-established as having the capacity to diff erentiate into cells with mesodermal, ectodermal, and endodermal characteristics; as well as a higher proliferative, adipogenic and endothelial diff erentiation potential than bone marrow mesenchymal stem cells (BMMSCs). Th e ability to modulate immune responses, on the other hand, makes HAMSCs an important compatible stem cell source for transplantation therapy in allogeneic settings without immunorejection. Here we propose a hypothesis that HAMSCs locally delivered via PCL nanothecnologic scaff old to skin burn wound could enhance wound healing through both diff erentiation into epithelial and endothelial cells and neoangiogenesis. In order to maximize the immunological incompatibility, HAMSCs would be injected to immunocompetent Guinea pigs. Th is could represent a novel therapeutic approach and enhance burn wound healing more eff ectively
Seyed Jafar Hashemian is a medical student in Tehran University of Medical Science. He is chief of student?s stem cells research committee of cellular and molecular research center in Iran University of Medical Science from Aug. 2010. He is the member of endocrinology and metabolism research center from Aug. 2011. He has published 3 papers. Kamran As?adi has completed degree of General Practitioner at 25 years of age at Shiras University of Medical sciences, Then straightly started specialty in General Surgery Residency in the same university for 4 years period. He got the Degree of National Board of General Surgery at 1994. Since that time he has been elected as Academic member of medical universities. From 1997 he started subspecialty in Plastic and Reconstructive Surgery in Tehran University of Medical Sciences, and got the degree of Board in Plastic and Reconstructive Surgery at 2000. He spent a complementary fellowship in craniofacial and breast reconstruction period in Henry Mondor Hospital in Paris School of Medicine. He visited plenty of Great experts in Plastic Surgery in reputable academic centers for training Plastic surgery around the United States. Since 2004 he has been Assistant Professor of Department of Plastic and Reconstructive Surgery at Tehran University of Medical Sciences. He has been elected as Member of American Society of Plastic Surgeons since 2005 and as an active member of International society of Aesthetic Plastic Surgery since 2008.
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