alexa T-type Calcium Channel Blocker, KCP10043F Inhibits G1 Cell Cycle Phase And Induces Apoptosis In Caspasedependent Pathway On Lung Adenocarcinoma
ISSN: 2376-0419

Journal of Pharmaceutical Care & Health Systems
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

10TH Asia-Pacific Pharma Congress
May 08-10, 2017 Singapore

Jeong hun Lee, Dong Gyu Leem, Dong Hyun Shin, Ji Sun Shin, Kyung-Tae Lee
Department of Life and Nonopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, South Korea
Posters & Accepted Abstracts: J Pharma Care Health Sys
DOI: 10.4172/2376-0419-C1-021
Abstract
KCP10043F (3,4-dihydroquinazoline derivative) is a selective T-type Ca2+ channel blockers and other studies showed that selective Ca2+ channel bloackers could inhibit the growth of cancer cells such as ovarian, lung, and pancreatic cancer cells. we now investigated that KCP10043F induced G1 arrest dose-dependently and cyclins and CDKs are regulated at protein expression level. In addition, KCP10043F made synergic effect on cell death with Etoposide, a novel anti-cancer agent. Then we continuously studied that KCP10043F induced apoptosis at high dose, detected by Annexin V-FITC / PI staining assay, and this cell death was dependent on caspase-activation, both capsase-3, 8 and -9. moreover, Bcl-2(anti-apoptotic protein), was down-regulated and Bax(pro-apoptotic protein) was up-regulated by this agent. This pathway was confirmed by using z-VAD-FMK, pan-caspase inhibitor, blocked the cell death induced by KCP10043F. Co-treatment with etoposide in low-dose also activated caspase-8,9. So our results suggested pathway how KCP10043F makes synergic effect on A549 cell line and it has possibility to be a potential anti-cancer agent reducing chemoresistance of lung cancers that show the lowest viability among many cancers.
Biography

Jeong hun Lee majored in Oriental Pharmacy at Kyunghee University, and now studying on master course, belonging to Department of Life and Nanopharmaceutical Science, Kyunghee University. He has studied about cancer biology, especially related with apoptosis and cell cycle arrest in cancer cells and how apoptosis is induced in specific cancer cells, like lung carcinoma, by using derivatives of natural product or chemical compositions.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version