Tumor interstitial fluid (TIF) is a proximal fluid that, in addition to the set of blood soluble phase-borne proteins, holds
a subset of aberrantly externalized components, mainly proteins, released by tumor cells and tumor microenvironment
through various mechanisms, which include classical secretion, non-classical secretion, secretion via exosomes and membrane
protein shedding. Consequently, the interstitial aqueous phase of solid tumors is a highly promising resource for discovery of
molecules associated with pathological changes in tissues. Firstly, it allows one to delve deeper into the regulatory mechanisms
and functions of secretion-related processes in tumor development. Secondly, the anomalous secretion of molecules that is innate
to tumors and the tumor microenvironment, being associated with cancer progression, offers a valuable source for biomarker
discovery and possible targets for therapeutic intervention. Here we provide an overview of the features of tumor-associated
interstitial fluids, based on recent and updated information obtained mainly from our studies of breast cancer. Data from the
study of interstitial fluids recovered from several other types of cancer are also discussed.
Gromov P is an Assistant professor at Danish Cancer Society Research Center. He completed his Ph.D. in 2005. He has published more than 25
papers in reputed journals and serving as an editorial board member of repute.
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