alexa Ubiquitin Ligase Itch Regulates P38α And Skin Inflammation Via Ubiquitination Of Tab1
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Psoriasis and Skin Specialists Meeting
December 08-09, 2016 Dallas, USA

Venuprasad Poojary
Baylor Research Institute, USA
ScientificTracks Abstracts: J Clin Exp Dermatol Res
DOI: 10.4172/2155-9554.C1.050
Abstract
Deficiency of the ubiquitin ligase Itch causes a scratching ‘Itchy’ phenotype. However, the precise molecular mechanisms by which Itch regulates skin inflammation remain unclear. We have found elevated activation of the kinase p38α in the spontaneous and experimentally induced skin lesions of Itch-/- mice. Mechanistically, we demonstrate that Itch binds directly to Tab1 via the conserved PPXY motif and negatively regulates p38α. ShRNA-mediated inhibition of Tab1 attenuated the prolonged p38α phosphorylation seen in Itch-/- cells. Similarly, reconstitution of WT Itch but not the Itch-C830A mutant (which lacks the ligase activity) inhibited p38α phosphorylation in Itch-/- cells. Since Itch-deficient mice are unable to regulate Tab1 and p38α, elevated levels of pro-inflammatory cytokines including TNF, IL-6, IL-1β, IL-11 and IL-19 were observed in the skin. Inhibition of p38 or blocking the interaction of p38α with Tab1 using a cell-permeable peptide dramatically attenuated skin inflammation in Itch-/- mice. These results provide new insights into how Itch-mediated regulatory mechanisms prevent chronic skin inflammation, which could be exploited therapeutically in chronic inflammatory skin diseases.
Biography

Venuprasad Poojary has completed his PhD in Immunology at the National Center for Cell Science, Pune, India and Postdoctoral studies from La Jolla Institute for Allergy Immunology in San Diego, CA. He is an Associate Investigator at the Baylor Institute for Immunology Research in Dallas, TX. He has published more than 25 papers in reputed journals.

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version