alexa
Reach Us +441414719275
Unconventional CD8+ T Cells (CD4dimCD8bright Cells) In Anti-HIV Immunity And Neuropathogenesis | 2258
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Unconventional CD8+ T cells (CD4dimCD8bright cells) in anti-HIV immunity and neuropathogenesis


Lena Al-Harthi

: J Antivir Antiretrovir

Abstract
C onventional paradigm of T cell biology tells us that expression of the CD4 and CD8 molecules on mature T cells is mutually exclusive. However, my group and others have identified a unique subset of CD8+ T cells that co-express CD4 dimly on their surface. This subset is termed CD4dimCD8bright T cells or double positive (DP) T cells. DP cells represent a genuine phenotype of CD8+ T cells. They express αβ TCR and αβ CD8 and are not prematurely released from the thymus. Post TCR or superantigen stimulation, 15-60% of purified CD8+ T cells induce stable CD4 expression on their surface. DP cells constitute 3-5% of peripheral CD8+ T cells in healthy donors and are expanded to up to 15% among HIV long-term nonprogressors. DP cells are highly enriched in anti-viral (CMV and HIV) responses. In comparison to their CD8 single-positive T cell counterparts, DP cells constitute greater than 55% of anti-HIV and -CMV responses, as evaluated by MHC-I tetramer analysis, polyfunctional cytokine and effector molecule expression, and antigen-specific proliferation. DP cells are also highly enriched in β -catenin expression, a pro-survival transcriptional co-activator that drives CD4 induction on CD8+ T cells and may protect them from activation-induced cell death. DP cells are found in the CNS of HIV-infected NOD/SCID/IL-2rcγ-/- mice reconstituted with human peripheral blood lymphocytes and while they are susceptible to HIV infection, they are not depleted to the same extent as CD4+ T cells. Astrocyte-conditioned media also induces CD4 expression on CD8+ T cells. Our findings identify DP cells as a potent anti-viral T cell subset; however, their contributing role to HIV-associated neurocognitive impairment, whether protective or pathogenic, remains to be elucidated
Biography
Dr. Al-Harthi is a Professor in the Department of Immunology/Microbiology at Rush University Medical Center in Chicago, IL. She has over 60 peer-reviewed publications and invited reviews/book chapters. Her research over the past 16 years has focused on HIV/host interactions, with a special emphasis on bridging basic and clinical science in the HIV/AIDS field. Because of her experience in HIV molecular biology, immunology, and neuroAIDS, she has been able to probe mechanistic questions that are clinically relevant to HIV/AIDS. She is actively investigating the molecular pathways by which Wnt/β-catenin signaling inhibits HIV replication, its impacts on HIV neuropathogenesis, and the role of host and viral factors in modulating β -catenin interaction with HIV.
Top