Journal of Hematology & Thromboembolic Diseases
Open Access

Unusual presentations of acute lymphoblastic leukemia in children: A systematic review

International Conference on Leukemia and Hematologic Oncology

October 17-18, 2016 Rome, Italy

Nader Shakibazad, Sezaneh Haghpanah and Mahdi Shahriari

Shiraz University of Medical Sciences, Iran

Scientific Tracks Abstracts: J Hematol Thrombo Dis

Abstract :

Introduction: Acute lymphoblastic leukemia (ALL) had common clinical presentation associated with bone marrow infiltration by leukemic cells. Rarely can it be presented with unusual signs related to extramedullary involvement that may be lead to delay diagnosis of ALL in children. Method: The following databases including PubMed, EMBASE, Science Direct and Google Scholar were searched for all relevant subjects from April 1986 to April 2016. To search for review articles, following terms alone or in combination were used: â�?�?Acute Lymphoblastic Leukemiaâ�?, â�?�?Unusual Presentationâ�?, â�?�?Childhood Leukemiaâ�?, â�?�?Rare Presentationâ�? and â�?�?Atypical Presentationâ�?. Inclusion criteria for this review study were all case reported study about unusual clinical presentations of acute lymphoblastic leukemia in pediatrics. Results: Of the total number of 56 studies, 41 had inclusion criteria. In this review study, the most common unusual initial presentation of ALL in children was related to musculoskeletal symptoms (34.2%) especially bony symptoms ( bone pain, multiple bone fractures, osteoporosis, multifocal osteomyelitis and calf pain) and hypercalcemia. The other unusual initial presentations of ALL in order of frequency include renal involvement (14.6%), neurologic signs (14.6%), orbital manifestations (12.2%), pericardial involvement (4.9%) and other rare miscellaneous presentations (19.5%). Conclusion: The clinician must be familiar with these unusual presentations of ALL in pediatrics in order to avoid delay diagnosis of this disease and increase survival by early detection.

Biography :

Nader Shakibazad has completed his MD and Pediatrician degree from Shiraz University of Medical Sciences, Shiraz, Iran. He has a Fellowship in Pediatric Hematology and Oncology. He has published more than 5 papers in reputed journals.

Email: nshakibazad@gmail.com