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|Grace Y Sun|
|University of Missouri, USA|
|ScientificTracks Abstracts: J Neurol Disord|
|Microglia is the major immune active cell in the brain, are known to play multiple functional roles for maintaining brain
health. Besides ability to migrate to sites of injury and scavenge cellular debris, these cells also become activated in
response to stimuli, including cytokines, chemokines and toxins. Upon activation, these cells release pro-inflammatory and
neurotrophic factors, this can alter the environment of neighboring cells. Microglia activation has been implicated in the acute
and chronic inflammation in a number of neurological diseases, including Alzheimer’s disease, stroke and traumatic brain
injury. Some noted pro-inflammatory events include activation of cytosolic phospholipase A2 (cPLA2) and stimulation of the
NF-kB transcriptional pathway. In our studies, we have used the bacteria endotoxins (lipopolysaccharides, LPS) to stimulate
the Toll-like receptors in microglia and activate both cPLA2 and the NF-kB pathway, leading to the release of prostaglandins,
pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO). A number of botanical polyphenols have
been shown to inhibit the oxidative/inflammatory responses elicited by LPS. Interestingly, some phytochemicals not only can
mitigate the NF-kB responses but also stimulate the anti-oxidant pathway involving the Nrf2 and activation of the Antioxidant
Response Element (ARE). The Nrf2/ARE transcription pathway is known to play an important role in the synthesis of a large
number of antioxidant enzymes including heme oxygenase-1 (HO-1). Although more studies are needed, there is evidence
that activation of MAPKs may play an important role in mediating the cross-talk between the NF-kB and Nrf2 pathways.
Future studies to uncover regulation of these pathways in microglia will be important in the development of novel therapeutic
strategies to fight against neurological diseases and aging.
1. Sun G Y, D Y Chuang (2014) Role of cytosolic phospholipase A2 in oxidative and inflammatory signaling pathways in different cell types in the central nervous system. Mol Neurobiol 50(1):6-14.
2. Sun G Y, Z Chen (2015) Quercetin attenuates inflammatory responses in BV-2 microglial cells: Role of MAPKs on the nrf2 pathway and induction of heme oxygenase-1. PLoS One 10(10): e0141509.
Grace Y Sun has completed her BS in Chemistry from Seattle Pacific University and PhD in Biochemistry from Oregon State University. After holding a Research Scientist position in Cleveland, she was recruited to the Biochemistry Department in University of Missouri. As a Neuroscientist, she is recognized for research on brain lipids and signaling pathways related to neuro-inflammation and aging. Her research experience included serving as Program Project Director of the MU Alzheimer’s disease research program and as a Project Leader in the MU Center for Phytonutrient and Phytochemistry. Besides training a large number of graduate students and post doctorates, she is also experienced in organizing national and international symposia and meetings. She has published over 300 articles in highly regarded journals. Among the many awards, the most notable one is the MU System President’s Award for Sustained Excellence in 2012, which was the highest award recognizing faculty achievement at the university.
Email: [email protected]
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