alexa
Reach Us +44-1904-929220
Using DNA Copy Number Aberrations In Naturally Occurring Canine Cancers To Identify Candidate Drivers Of Carcinogenesis | 19519
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

2nd International Conference on Genomics & Pharmacogenomics

Daniel Rotroff, Rachael Thomas, Sarah Roode, Alison Motsinger-Reif and Matthew Breen
ScientificTracks Abstracts: J Mol Genet Med
DOI: 10.4172/1747-0862.S1.002
Abstract
There are approximately 78 million domestic dogs residing in the USA. Cancer is one of the leading causes of death for domestic dogs, with popular breeds such as golden retrievers, Labrador retrievers and boxers, succumbing to cancer with frequencies of 50, 34 and 44%, respectively. Because canines exhibit a wide variety of spontaneous cancers that share clinicopathologic features with humans, we have a unique opportunity for comparative analysis of naturally occurring cancers toward advancing treatment strategies in both species. Furthermore, the recent development of a high-quality canine genome sequence assembly has opened the door for researchers to identify key drivers of disease that may impact both canine and human patients. We have developed tumor-associated genomic DNA copy number aberration profiles for 75 canine hemangiosarcomas and more than 200 canine leukemias and lymphosarcomas using an oligonucleotide array comparative genomic hybridization (oaCGH) platform. Using a variety of bioinformatic approaches we have mapped canine genes to available human homologues for pathway-based analyses, identified putative drivers of carcinogenesis, and have identified genes that may be useful as diagnostic tools for characterizing leukemia subtypes. Overall, these results demonstrate the potential for using spontaneously occurring canine cancers to improve diagnoses and develop novel therapies for both dogs and humans.
Biography
Daniel Rotroff has completed his MSPH and his PhD from the University of North Carolina at Chapel Hill and is currently a Postdoctoral research scholar at North Carolina State University in the Department of Statistics. His graduate work was conducted within the ToxCast project at the National Center for Computational Toxicology at the US EPA and focused on predictive modeling of the estrogen receptor signaling pathway. He is currently focused on association mapping and predictive modeling for a wide range of pharmacogenomics applications.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version