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Using Human Adenovirus As A Novel Approach For Campylobacter Jejuni Vaccine Development To Prevent Colonization Of Chickens | 3312
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Using human adenovirus as a novel approach for Campylobacter jejuni vaccine development to prevent colonization of chickens

Sonja Mertins, Brenda J. Allan, Suresh K. Tikoo, Wolfgang K?ster and Andrew A. Potter

: J Vaccines Vaccin

Objectives: Tuberculosis is a serious health problem in developing countries. One way to overcome this is to offer immunization to all newborns using BCG vaccine. BCG vaccine is safe but known to be associated with complications. The aim of this report was to evaluate the safety of BCG vaccine in Eastern Province, Saudi Arabia and outline our management for BCG vaccine related complications. Methods: The records of infants with BCG vaccine complications were retrospectively reviewed for: age, sex, birth weight, gestation, presentation, treatment and outcome. All were immunized (BCG vaccine SSI, Copenhagen, Denmark, 0.05 ml injected intradermally in the left arm by a constant group of 3 trained nurses) within 48 hours after birth. Results: Over a 3 years period (10.3.2008 to 10.3. 2011), 26,000 newborns received BCG immunization and 81 (51 M and 30 F) developed complications. This gives an incidence of 3.12 complications/1000 newborn. Their mean age was 4.8 months (2 months ? 12 months). Their presentations were: (L) axillary lymphadenitis (n= 62), (L) supraclavicular lymphadenitis (n= 9), local collection at immunization site (n= 6), (L) cervical lymphadenitis (n= 1), bilateral axillary lymphadenitis (n= 1), (L) arm abscess (n= 1) and (L) axillary lymphadenitis and local collection (n= 1). All were normal immunologically except two (SCID and HIV). These received anti-tuberculous drugs in addition to surgery. The 6 with localized collection were aspirated only while the patient with (L) arm abscess had incision and drainage. Those with simple lymphadenitis (n=5) were treated expectantly and resolved. The patients with suppurative lymphadenitis were treated with total excision (n= 65) or incision and drainage (n= 3) without anti-tuberculous treatment. Conclusions: Although, the use of BCG vaccine may be associated with side effects (a relatively high incidence of suppurative lymphadenitis), the potential morbidity and mortality from tuberculosis outweighs that from BCG related complications. BCG vaccine should be administered to all newborn where there is high prevalence of tuberculosis. BCG is contraindicated for immuodeficient infants. Non-suppurative lymphadenitis can be treated conservatively, while suppurative lymphadenitis should be excised. This is safe, avoids rupture and shortens the recovery period without the need for anti-tuberculous therapy.
Graduated in October 1981 from King Faisal University, College of Medicine and Medical Sciences, Dammam, Saudi Arabia. Awarded prize for best Graduate of the Year. In January 1985, awarded prize by the Royal College of Surgeons of Ireland as the best candidate in the Primary FRCSI Examination. In February 1987 awarded the Fellowship from The Royal College of Surgeons of Ireland. Currently working as a consultant pediatric surgeon and consultant pediatric urologist at Maternity and Children Hospital, Dammam, Saudi Arabia. Published more than 245 papers in reputed Journals. Reviewed more than 80 manuscripts for different Journal. Serving as an Editorial Board member of three Journals.