alexa VacA And CagA Genotypes Of H. Pylori And IFN-γ Expression In Chronic Gastritis And Gastric Cancer Patients
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Congress on Bacteriology & Infectious Diseases
November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Mart?nez-Carrillo Dinorah Nashely, Atrisco-Morales Josefina, Reyes-Navarrete Salom?n, Betancourt-Linares Reyes, Hern?ndez-Pando Rogelio, Illades-Aguiar Berenice, Rom?n-Rom?n Adolfo and Fern?ndez-Tilapa Gloria
Posters: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.003
Abstract
Helicobacter pylori represents the major cause of chronic gastritis, duodenal and gastric ulcer and gastric cancer. Clinical outcome of H. pylori infection is determined by the virulence factors of bacteria, environment and immune response of the host. A differential expression of cytokines between H. pylori positive and H. pylori negative patients or between gastritis and gastric cancer patients was reported. The aim of present study was to compare the IFN-γ expression between vacA and cagA genotypes of H. pylori in chronic gastritis and gastric cancer patients. Ninety-six patients with chronic gastritis and twenty with gastric cancer were recruited. H. pylori infection, vacA and cagA genotyping were accomplished via PCR from total DNA of gastric biopsies, the IFN-γ expression was determined by immunohistochemistry. Of the patients overall, 66 (56.9%) were infected with H. pylori, among patients with chronic gastritis 54 (56.3%) and 12 (60%) in gastric cancer were H. pylori positive. The predominant vacA and cagA genotypes of H. pylori were vacAs1m1 (87%) and cagA positive (77.8%) in chronic gastritis and 83.3% and 58.3% in gastric cancer. We observed a variation of expression of IFN-γ in patients with chronic gastric infected with H. pylori vacAs1m2 (83%) compared with vacAs1m1 (82%) and s2m2 (72%) genotypes and in patients infects with H. pylori cagA positive (82%) respect to H. pylori cagA negative (78.2%), similar dates were found in gastric cancer groups. The IFN-γ expression and vacA and cagA genotypes of H. pylori could be important factors that increase the damage in gastric mucosa.
Biography
Mart?nez-Carrillo Dinorah Nashely has completed her master?s degree at the age of 29 years from Universidad Aut?noma de Guerrero. She has published 4 papers in reputed journals. She is currently pursuing her Ph.D.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords