Value Of Cytopathology In The Diagnosis Of Respiratory Diseases | 34205
Journal of Cytology & Histology
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Although the cytology (cytopathology) was first used as a diagnostic tool in the lung disease in early 1900s, it is not until
the 1960s that pulmonary cytology becomes a diagnostic discipline. Since then, tremendous improvements have been
made due to the innovation of sample collection and preparation techniques. The commonly used respiratory specimens in
clinical diagnosis include: sputum, bronchial brushing and washing, bronchoalveolar lavage (BAL), transbronchial fine needle
aspiration (TBNA), endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-TBNA) and transthoracic
CT or ultrasound-guided fine needle aspiration (FNA). The familiarity of cyto morphological features of respiratory cells and
current techniques of obtaining samples are crucial to make an accurate diagnosis. Similar to other type of non-gynecologic
cytological specimens, the diagnoses of respiratory diseases are typically made based on the cyto morphological evaluation
of respiratory cells. In addition, an explanation note of the diagnosis is often used in the report at our institution to report
immunohistochemical and molecular results and also provide suggestions to our clinical colleagues if necessary. In this
presentation, we will discuss the cyto morphological findings of both benign and malignant respiratory diseases and the
differential diagnosis of lung cancers.
Qing Kay Li is an internationally recognized expert in the field of cytopathology and Co-PI in Johns Hopkins Biomarker Discovery Center. She provides diagnostic service at Johns Hopkins and Conducts Research in the field of novel biomarkers in lung and prostate cancers. Her research has been presented at many national/international meetings. She also serves as Editorial Board Member for several journals, committee member of the American Society of Cytopathology and study sections of government agents and private organizations. She has more than 70 publications and book chapters. She is also the Editor of “Diagnostic Cytopathology Board Review and Self-Assessment”.