alexa Variety Of Immunoglobulin G Functions
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

8th Molecular Immunology and Immunogenetics Congress
March 20-21, 2017 Rome, Italy

Roald Nezlin
Weizmann Institute of Science, Israel
Posters & Accepted Abstracts: J Immunome Res
DOI: 10.4172/1745-7580.C1.012
Abstract
Immunoglobulins are multifunctional protein molecules. In recent years several new functional activities of IgG were found in the studies of non-immune IgG complexes with various proteins. Serum contains thousand proteins of various origin and properties, synthesized by cells of the liver, spleen and other organs. IgG molecules could serve as scavengers, removing proteins that are potentially harmful to the body like anaphylatoxins, small toxic proteins of complement protein superfamily (“cleansing” IgG function). The properties of non-immune IgG complexes differ from those of their individual components. Various receptors are located on the surface of cells together with Fc-receptors and IgG complexes with active ligands can interact simultaneously with these two different types of cell receptors. During the past decade, it was found that glucose-regulated cell proteins including Grp94 are overexpressed in malignant cells of both solid and hematological tumors. Increased production of Grp94 is correlated with the progression of carcinogenesis and metastasis. Grp94 molecules can release into the circulation and form stable non-immune complexes with IgG. The detection of Grp94-IgG complexes has important clinical significance in pathologies with the Grp94 overexpression. The IgG complexes facilitate the detection of biomarkers as well as their isolation by specific adsorption properties of IgG. The adsorption of IgG complexes by bacterial Protein G helps to evaluate the exact amount of IgG partners in the complexes by quantitative immunochemical methods.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords