alexa Vascular Aging And Melatonin Beneficial Effects
ISSN: 2167-7182

Journal of Gerontology & Geriatric Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

International Conference on Geriatrics & Gerontology
July 08-10, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Rita Rezzani, Favero G, Franceschetti L and Rodella L F
Accepted Abstracts: J Gerontol Geriat Res
DOI: 10.4172/2167-7182.S1.004
In the last decades the worldwide population has exhibited an increasing life expectancy with a consequent rise in the elderly population; the increase of human life expectation has important health and socioeconomic consequences. The ageassociated infirmities that accompany increased life expectancy involve cardiovascular diseases, which include diabetes, stroke, heart attack, heart failure, hypertension and neurodegenerative disease. Melatonin, the pineal indoleamine, shows remarkable function versatility exhibiting antioxidant, oncostatic, immunomodulatory and anti-aging properties. The aim of this study was to investigate parameters such as morphological alterations, inflammation and oxidative stress at the aorta level of an animal model of senescence and the effects of chronic administration of melatonin. Twenty male senesce prone mice (SAMP8) and twenty control mice, senescence resistant mice (SAMR1), were analyzed untreated or after chronic treatment with melatonin at the dose of 10 mg/kg/day in the drinking water from the 1st to the 10th month of age. The results showed that aging induced a significative increase of tunica media thickness in the aorta. In addition, we showed an increase in endothelin-1 expression and of inflammation and oxidative stress parameters compared to control mice (SAMR1). Melatonin chronic administration partially ameliorated all these age-related alterations. In summary, this study support the existence of inflammatory and oxidative stress processes during aging and suggest that melatonin behaves as an essential indoleamine against aging, for its antinfiammatory properties together with its antioxidant role.
Rita Rezzani is Full Professor of Human Anatomy and Chair of Anatomy and Physiopathology Section at University of Brescia (Italy). Her scientific fields regard the immunosuppressive effects of cyclosporine A, the oxidative stress and the morphological alterations induced by cardiovascular diseases. Recently her interest involves the beneficial effect of natural antioxidants, in particular of melatonin, in several diseases. She is interested to study both the therapeutic and protective melatonin effects. She is author of 180 full-length publications and she participated to write several books.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version