alexa Vasodilatory Effect Of Hydroxyethyl Methacrylate And Triethylene Glycol Dimethacrylate In Rat Aorta Through Calcium Antagonistic Action
ISSN: 2161-1122

Dentistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

19th American Dental Congress
December 08-10, 2016 Phoenix, USA

Oguzhan Yildiz
Gulhane School of Medicine, Turkey
Posters & Accepted Abstracts: Dentistry
DOI: 10.4172/2161-1122.C1.009
Abstract
Resin-based dental materials contain various diluent monomers that can interfere with vascular function by causing vasodilation. In this study, we evaluated the vasoactive potential of hydroxyethyl methacrylate (HEMA) and triethylene glycol dimethacrylate (TEGDMA), and the possible mechanism of their vascular action on isolated rat aorta. Responses of thoracic aorta rings were recorded isometrically by using force displacement transducers. After pre-contracting aorta rings with phenylephrine, relaxations to HEMA and TEGDMA were recorded in the absence and presence of nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester, cyclooxygenase inhibitor indomethacin and K+ channel inhibitors: tetraethylammonium, glibenclamide and 4-aminopyridine. To investigate the Ca2+-channel antagonistic effect of HEMA and TEGDMA in different aorta rings, concentration-response curves to CaCl2 were obtained in the absence and presence of the test monomers. Both HEMA and TEGDMA elicited concentrationdependent relaxations. The vasorelaxant effect of HEMA and TEGDMA was not mediated via endothelium-dependent NO and prostanoid-dependent mechanisms, or by K+ efflux through K+ channels. Both monomers significantly inhibited the contractions induced by CaCl2. Our results show that HEMA and TEGDMA induce vasodilation via Ca2+-antagonistic action, while NO and cyclo-oxgenase pathway and K+ channels were not responsible for this vasoactive effect.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords