alexa VCG Modulate Innate And Adaptive Immunity To Vaccine Antigens | 62892
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

15th Annual Summit on Vaccines and Immunization

Yusuf Omosun, Q He, J U Igietseme and F O Eko
Morehouse School of Medicine, USA
Centers for Disease Control and Prevention, USA
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.C1.054
Abstract
Statement of the Problem: Vaccination strategies utilizing subunit antigens often rely on the incorporation of effective adjuvants to modulate immune responses. Vibrio cholerae ghosts (VCGs; genetically derived empty V. cholerae cell envelopes) constitute an effective delivery system that promotes the induction of protective immunity in the absence of external adjuvants. However, the mechanism by which VCGs enhance immunity has not been elucidated. We hypothesized that the immunostimulatory ability of VCGs involves dendritic cell (DC) activation and function. Aim: Aim of this study is to evaluate the immunomodulatory effect of VCGs on induction of innate and adaptive immune responses. Methodology & Theoretical Orientation: Mouse bone marrow-derived DCs (BMDCs) co-cultured with VCG or UV-irradiated Chlamydia elementary bodies (UV-EBs) were stained with monoclonal antibodies against co-stimulatory molecules and surface expression was analyzed by flow cytometry. The magnitude of cytokines secreted by culture supernatants or splenocyte-stimulated cultures was analyzed by cytokine ELISA. Furthermore, the ability of VCG-pulsed DCs to present chlamydial antigen to infectionsensitized CD4+ T cells and enhance the protective immunity of chlamydial antigens was also evaluated. Results: VCG-pulsed DCs showed increased secretion of proinflammatory cytokines and expression of co-stimulatory molecules associated with DC maturation in response to stimulation with UV-EB. Also, co-culture of VCG with DCs resulted in effective chlamydial antigen presentation and enhancement of protective immunity. Conclusion & Significance: These results demonstrate that VCGs activate the maturation of DCs leading to enhancement of innate and adaptive immunity to a co-delivered antigen. The results highlight the potential of the VCG as immunomodulators for enhancement of protective immunity against microbial infections.
Biography

Yusuf Omosun is involved in research aimed at understanding how Chlamydia infection increases the risk of developing tubal factor infertility (TFI), and finding ways to ameliorate this process through more efficient diagnosis or the discovery of viable vaccines. This would have a tremendous impact in women's reproductive health by reducing the detrimental pathology of Chlamydia.

Email: [email protected]

image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7