alexa Vegetables? Juice: Potent Inhibitors Of Polyol Pathway Induced Oxidative Stress | 13933
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

International Conference on Pharmacognosy, Phytochemistry & Natural Products

Anand Kumar D, Pisupati S. R Sweeya, Lavanya Vadala, Anusha Chauhan H, Pavithra Konda, Sireesha Kayyuru, Amtul Zehra and Ashok Kumar Tiwari
Posters: Biochem & Pharmacol
DOI: 10.4172/2167-0501.S1.003
Abstract
Oxidative stress plays important role in stimulating pathogenesis of diabetic complications by free radicals mediated damage of biomolecules. Hyperglycemia induced oxidative stress develops through multiple mechanisms. Polyol pathway has been recognised as an important mechanism that contributes to the development of oxidative stress. Under hyperglycemic conditions, glucose is channelled into aldose reductase dependent polyol pathway which depletes NADPH and consequently reduces the level of enzymatic antioxidant GSH. During SDH mediated conversion of sorbitol into fructose, NAD + is converted to NADH which is substrate for NADH oxidase responsible for increased generation of free radicals. Conversion of fructose into Fructose-3-phosphate and 3-deoxyglucosone leads increased formation of non-enzymatic glycation end products. Reduction in antioxidant enzymes, increased generation of free radicals and consequently oxidative modification of biomolecules increases level of oxidative stress. Ten commonly consumed vegetables were evaluated for their aldose-reductase inhibitory, antioxidative stress and antioxidant potentials. Study revealed that vegetables? juice prevented utilization of NADPH by aldose-reductase and hence, reduced aldose reductase activity. Vegetable?s juice mitigated formation of sorbitol in human erythrocytes under different glycemic conditions. Vegetable?s juice also prevented hemolysis from erythrocytes and 2-deoxy-D-ribose oxidation induced by hydroxyl radicals and displayed antioxidative stress and antioxidant activities. Vegetables? juices are rich source of polyphenols, flavonoids and proteins. In the order of their overall potentials, ivy gourd and ridge gourd juice were identified most potent aldose reductase inhibitors and antioxidative stress agents. These observations endorse that vegetables can become economical source in preventing development of diabetic complication by multiple mechanisms.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7