alexa
Reach Us +44-1904-929220
Viral Colonization In Exhaled Breath Condensate Of Lung Cancer Patients: Possible Role Of EBV And CMV | 8945
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Viral colonization in exhaled breath condensate of lung cancer patients: Possible role of EBV and CMV

4th International Conference on Biomarkers & Clinical Research

Giovanna E. Carpagnano1, Donato Lacedonia, Maria Iole Natalicchio, Luigi Zoppo, Valerio Saliani, Domenico Martinelli, Raffaele Antonetti, Silvio Orlando and Maria P Foschino-Barbaro

AcceptedAbstracts: J Mol Biomark Diagn

DOI: 10.4172/2155-9929.S1.019

Abstract
T oday an increasing interest is being addressed to the viral aetiology of lung tumours. As a consequence, research efforts are actually being directed to the identification of the new viruses involved in lung carcinogenesis toward which the screening programs could be directed. Aim: The aim of this study was to investigate the airways colonization by Epstein Barr virus (EBV) and Citomegalo virus (CMV) in patients affected by lung cancer using, as a respiratory non-invasive sample, the exhaled breath condensate (EBC). Material and methods: 70 lung-cancer patients and 40 controls were enrolled. All subjects underwent bronchial brushing and EBC collection. EBV-DNA and CMV-DNA were evaluated in both samples by real-time PCR assay. Results: We were able to detect EBV and CMV in the EBC. We observed an increase of the EBV positivity in NSCLC patients compared to controls, and of the CMV in advanced stages of lung cancer. The association of the positivity of the cytology and the CMV test (in EBC or brushing) slightly increased the sensibility of malignant diagnosis. Conclusion: In conclusion, EBV and CMV resulted detectable in the EBC. In consideration of the potential involvement of these viruses in lung cancer, also confirmed in this study, we support future studies in this direction.
Biography
Relevant Topics
Top