Virally Induced Cancers: A Unique Paradigm To Study The Link Between Carcinogenesis And Stemness | 38342
Journal of Cancer Science & Therapy
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Intra-tumor phenotypic heterogeneity, along cancer progression, gives rise to cells that express different lineage markers and have
diverse functions. Recent studies in various cancers show that as the tumor progresses, tumor cells become increasingly plastic.
Oncogenic transformation often yields cells with unlimited self-renewal potential by cellular reprogramming, comparable to those
in the iPSC generation process. We are studying this complex similarity and asking when and how the cells acquire properties of
stemness during cancer. Our chosen model for these investigations is virally induced cancers. Besides being a cause of 10-15% of
cancers worldwide, virus associated malignancies have identifiable non-cellular targets that make them valuable systems. Merkel
cell carcinoma: Merkel cell polyoma virus (MCV) causes a rare, lethal skin cancer called Merkel cell carcinoma (MCC). A stemnessrelated,
anti-apoptotic protein, called survivin, shows differential expression when deep-sequence profiles of MCC with and without
the virus are compared. Also, both gain and loss of function studies show a substantial correlation between survivin and MCV large T
onco-protein. Further I will present how targeting survivin using an inhibitor initiated selective MCV (+) MCC cell death and halted
xeno-graft tumor growth in mice. Cervical cancer: Cervical cancers, a malignancy associated with oncogenic papilloma viruses,
remain a major disease burden in the absence of effective implementation of preventive strategies. CD66 (+) cells have previously
been identified as a tumor-propagating subset in cervical cancers, showing a mixed stemness and differentiation phenotype. I will
present our investigations on a CD49f (-) subset of these CD66 (+) cells associated TGFβ treatment and shows an increased migration
rate possibly accounting for cancer metastasis.
Reety Arora is a Welcome Trust-India Alliance Early Career Fellow in Prof. Sudhir Krishna’s group at NCBS, India. She completed her PhD in Dr. Yuan Chang and Dr. Patrick Moore’s laboratory at University of Pittsburgh where her work contributed to a new human cancer virus, MCV being classified as a WHO carcinogen for skin cancers. She briefly worked at inStem, Bangalore as a Post-doctoral fellow on quiescence in muscle stem cells before independently securing a grant for studying shared mechanisms in stemness and carcinogenesis using tumor viruses.