alexa VISTA Deficiency Synergizes With A Non-redundant Immune Checkpoint Pathway And Leads To Enhanced Immune Activation
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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3rd International Conference and Exhibition on Clinical & Cellular Immunology
September 29-October 01, 2014 DoubleTree by Hilton Baltimore-BWI Airport, USA

Li Wang
ScientificTracks Abstracts: J Clin Cell Immunol
DOI: 10.4172/2155-9899.S1.017
Abstract
V-domain Ig suppressor of T cell activation (VISTA) is a novel negative checkpoint ligand that suppresses T-cell mediated immune responses. Previous studies using VISTA-neutralizing monoclonal antibody show that VISTA-blockade enhances T cell-activation in an inflammatory disease model EAE, as well as in murine tumor models. Current study describes a comprehensive characterization of VISTA knockout (KO) mice. We show that despite the apparent normal hematopoietic development in young KO mice, VISTA genetic deficiency leads to a pro-inflammatory phenotype in aged animals, as well as enhanced T-cell activation in response to acute antigen immunization. In addition, we show that VISTA deficiency significantly enhanced disease development in a spontaneous model of autoimmune disease, which is correlated with the spontaneous activation of auto-antigen specific CD4+ T cells. Lastly, when combined with the genetic deficiency of another checkpoint molecule, synergistic or additive immune activation was observed.
Biography
Li Wang completed her PhD at Molecular and Cellular Biology Program at Dartmouth,and completed her Postdoctoral studies with Dr. Owen N Witte at UCLA, as well as with Dr. Randolph J Noelle at Geisel School of Medicine at Dartmouth. She made seminal findings of a novel immune checkpoint regulator, named V-domain Immunoglobulin Suppressor of T cell activation (VISTA). She joined the Department of Microbiology and Immunology as an Assistant Professor in 2012.
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