alexa Vitamin D Deficiency And Its Effect On Hematopoietic Stem Cell Transplant Recipient | 64908
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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7th World Hematologists Congress

Hawazen Alsaedi
King Faisal Specialist Hospital and Research Centre, Saudi Arabia
Posters & Accepted Abstracts: J Blood Disord Transfus
DOI: 10.4172/2155-9864-C1-023
Abstract
Vitamin D plays an important role in calcium metabolism and homeostasis. In addition to its role in calcium metabolism, vitamin D plays an important role as immunomodulator. Vitamin D receptor (VDR) is expressed on many cells including T, B and natural killer (NK). Vitamin D modulates both innate and adaptive immune response. Recently, vitamin D deficiency is linked to cancer, autoimmune diseases and graft versus host disease (GVHD). This study investigated the effect of vitamin D deficiency in 104 children who underwent hematopoietic stem cell transplant (HSCT) from 2012 to 2015. Vitamin D level was measured prior to HSCT and serial measurements after HSCT on days 30, 60, 100 and 365 days. We observed that low vitamin level below 30 ng/ ml is strongly associated with increased risk of relapse and decrease survival at day 100-post hematopoietic stem cell transplantation (HSCT) p=0.04. Also, we observed a strong correlation between low vitamin D level and infections including fungal and CMV reactivation post HSCT p=0.004. To conclude, vitamin D plays an important role as immunomodulator; its deficiency may impact the outcome of patient undergoing HSCT. Optimizing nutritional supplementation is very important before transplantation and continues after HSCT.
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