Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Mohamad Irani
Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, USA
Posters & Accepted Abstracts: Endocrinol Metab Syndr
Background: There is an abnormal increase in TGF-�?²1 bioavailability in women with polycystic ovary syndrome (PCOS), which might play a role in the pathophysiology of this syndrome. Vitamin D (VD) supplementation improves various clinical manifestations of PCOS and decreases TGF-�?²1 levels in several diseases including myelofibrosis. Aim: The objective of the study was to determine the effect of VD supplementation on TGF-�?²1 bioavailability in VD-deficient women with PCOS and assess whether changes in TGF- �?²1/soluble endoglin (sENG) levels correlate with an improvement in PCOS clinical manifestations. Method: Prospective, randomized, placebo-controlled trial was used. 68 VD-deficient women with PCOS who were not pregnant or taking any exogenous hormones were recruited between October 2013 and January 2015. Forty five women received 50000 IU of oral vitamin D3 and 23 women received oral placebo once weekly for eight weeks. Serum TGF-�?²1, sENG, lipid profile, testosterone, dehydroepiandrosterone sulfate, and insulin resistance were measured. The clinical parameters were evaluated before and two months after treatment. Results: The VD level significantly increased and normalized after VD supplementation (16.3�?±0.9 [SEM] to 43.2�?±2.4 ng/mL; P<.01), whereas it did not significantly change after placebo. After the VD supplementation, there was a significant decrease in the following: the interval between menstrual periods (80�?±9 to 60�?±6 d; P=.04), Ferriman-Gallwey score (9.8�?±1.5 to 8.1�?±1.5; P<.01), triglycerides (138�?±22 to 117�?±20 mg/dL; P=.03), and TGF-�?²1 to sENG ratio (6.7�?±0.4 to 5.9�?±0.4; P=.04). In addition, the TGF-�?²1 to sENG ratio was positively correlated with �?�? triglycerides (r=0.59; P=.03). Conclusions: VD supplementation in VD-deficient women with PCOS significantly decreases the bioavailability of TGF-�?²1, which correlates with an improvement in some abnormal clinical parameters associated with PCOS. This is a novel mechanism that could explain the beneficial effects of VD supplementation in women with PCOS. These findings may support new treatment modalities for PCOS, such as the development of anti-TGF-�?²1 drugs.
Email: mohamad.irani@hotmail.com