alexa Vitiligo And Hyperpigmentation Disorders - What?s Mutual?
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
Open Access

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Previously: Journal of Pigmentary Disorders

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VI Master Class on Vitiligo and Pigmentary Disorders and Innovative Therapy in Dermatology Symposium, Split, Croatia, May 1-3, 2015

Ivana Binić
Conference Proceedings: Pigmentary Disorders 2015
DOI: 10.4172/2376-0427.S11-009
Abstract
Cutaneous pigmentation is the outcome of two important events: the synthesis of melanin by melanocytes and the transfer of melanosomes to surrounding keratinocytes. Although the number of melanocytes in human skin of all types is essentially constant, the number, size, and manner in which melanosomes are distributed within keratinocytes vary. Pigmentation disorders include a large number of heterogeneous conditions that are usually characterized by altered melanocyte density, melanin concentration, or both, and result in altered pigmentation of the skin. Melanin production results from strong cellular and molecular connections between all cell populations in the skin and the key players besides melanocytes, are fibroblasts and keratinocytes. Minor changes in the cellular physiology of the skin can dramatically affect pigment production in positive or negative manners. When disturbed, it may determine different types of pigmentation defects, which are classified which may occur with or without an altered number of melanocytes.These two groups of disorders are different, but in the center of both is melanocyte with all associated cells, processes, regulatory genes. Key questions that remain to be answered include what are the signal (s) that modulate melanocyte stem cells? awakening from and return to quiescence and to determine what are the signals modulating melanocyte death during catagen? Also, interesting questions may be about role of vitamin D and calcium in regulating process of pigmentation. Despite the differences between vitiligo and hyperpigmentation disorders, a better understanding of their etiopathogenesis and all the complex interactions between regulators of the melanogenesis and finding their mutual characteristics will help in the future in finding better therapeutic options for both types of disorders
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