Hematopoesis is the formation of blood cellular components. The effect of growth factors and hormones
(erytrhopoetin, thyroid and corticosteroid hormones) are important in producing of erythrocytes. The author would thorugh
the presentation, like to present a panhypopituitarism with hypoproliferative anemia case to point out endocrine disorders in
differential diagnosis of anemia.
A 36-year-old man without any significant past medical history presented to the hematology outpatient clinic with
generalized waekness for a long time. Further questioning revealed a remote history of head trauma and scalp fracture which
was occured around 5 years ago. Labaratory findings revealed anemia with 7.2 g/dl hemoglobine level and reticulocytopenia.
Bone marrow biopsy was performed to evaluate his anemia and 30% of bone marrow cellularity was found. Endocrinology
consultation was requested due to abnormal thyroid function test. Patient?s panel of anterior hypohysis hormones was detected
as the following; FSH=0.572 mIU/ml, LH=0.100 mIU/ml, prolactin=28.26 ng/ml, testosterone=0.025 ng/ml, cortisol=1.97
mcg/dl, GH=0.281 ng/ml, ILGF-1=25 ng/ml, TSH=4.15 uIU/ml, free-T3=1.32 ng/dl, FT4=0.48 ng/dl. Cranial and hyphopysis
MRI scan was carried out due to panhypopituitarism pre-diagnosis. MRI revealed variation of hypothalamo-hypophysis
anatomy and posteriorly located infindibulum. Bilaterally small testicals was found during testicular ultrasonography.
As a conclusion, it is emphasized that endocrine disorders needs to be considered in diagnosis of anemia since the
nonspesific symptoms such as weakness, fatigue might be seen in both condition.
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals