alexa WGX-50, A Drug Candidate From Sichuan Pepper And Its Potential Role Against Ad And In Antiaging
ISSN: 2161-0444

Medicinal Chemistry
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

5th International Conference on Medicinal Chemistry & Computer Aided Drug Designing and Drug Delivery
December 05-07, 2016 Phoenix, USA

Dong-Qing Wei
Shanghai Jiaotong University, China
Posters & Accepted Abstracts: Med chem
DOI: 10.4172/2161-0444.C1.028
Based on structure of membrane protein targets acquired by bioinformatics tools and database of molecules extracted from the Traditional Chinese medicines, various cheminformatics procedures were performed to screen for potential active compounds. Many promising molecules were obtained, for example, agaritine and wgx-50 was singled out through similarity search, molecular docking and molecular dynamics simulations. In vivo, the pharmacological kinetics profiles of wgx-50 were obtained to evaluate the effect of wgx-50 on cognition ability of scopolamine induced acute memory damage mice and Amyloid Precursor Protein transgenic (APP-Tg) mice by Morris water maze testing (MWM) and the β-amyloid (Aβ) oligomerics in the brain of APP-Tg mice by immunohistochemisty. In vitro, the direct effect of wgx-50 on Aβ oligomerics was observed by the atomic force microscope; the neurocyte protection by Western blot and cell apoptosis assay; and measured intracellular calcium current ([Ca2+]i) by Laser confcal microscopy. Experiments in vivo showed that wgx-50 could penetrate the blood brain barrier and improve the cognition ability and decrease the Aβ oligomeric accumulation on cerebral cortex. Results in vitro displayed that wgx-50 could disassemble the Aβ oligomerics, inhibit Aβ-induced neurocyte apoptosis as well as apoptotic gene expression, and relieve neuron calcium intoxication. These results strongly suggest that wgx-50 possess biologic functions against AD. Discoveries were also made in its potential role in anti-aging.

Email: [email protected]

image PDF   |   image HTML
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version